Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Reexamination Certificate
2008-03-17
2011-12-13
Landsman, Robert (Department: 1647)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
C530S387300, C530S387900, C530S388100, C530S388150, C435S007100
Reexamination Certificate
active
08076458
ABSTRACT:
An object of the present invention is to provide a monoclonal antibody which is useful as a diagnostic agent or a therapeutic agent for a disease relating to a polypeptide encoded by Claudin-4 (hereinafter referred to as “CLDN4”) gene or a polypeptide encoded by a Claudin-3 (hereinafter referred to as “CLDN3”) gene, or a method for using the same. Accordingly, the present invention provides a monoclonal antibody or an antibody fragment thereof, which specifically recognizes three-dimensional structure of an extracellular region of CLDN4 and binds to the extracellular region; a monoclonal antibody or an antibody fragment thereof, which specifically recognizes three-dimensional structure of both of extracellular regions of CLDN3 and CLDN4 and binds to the extracellular regions; a hybridoma which produces the antibody; a DNA which encodes the antibody; a vector which comprises the DNA; a transformant obtained by transforming the vector; a process for producing an antibody or an antibody fragment thereof using the hybridoma or the transformant; and a diagnostic agent or a therapeutic agent for a disease relating to a polypeptide encoded by CLDN4 gene and/or CLDN3 gene using the antibody or the antibody fragment.
REFERENCES:
patent: 6632927 (2003-10-01), Adair et al.
patent: 2005/0074798 (2005-04-01), Sukumar et al.
patent: 2006/0084594 (2006-04-01), Santin et al.
patent: 2103628 (2009-09-01), None
patent: 2006-525351 (2006-11-01), None
patent: 00/26360 (2000-05-01), None
Offner, 2005, Cancer Immunology Immunotherapy, vol. 54, pp. 431-455.
Amit et al., 1986, Science, vol. 233, No. 4765, pp. 747-753.
Panka et al., 1988, Proc. Natl. Acad. Sci. USA, vol. 85, pp. 3080-3084.
Rudikoff et al., 1982, Proc. Natl. Acad. Sci. USA, vol. 79, pp. 1979-1983.
International Search Report (PCT/ISA/210) issued Apr. 15, 2008 in corresponding PCT/JP2008/054769.
Anonymous: “Mouse anti claudin-4 antibody”, invitrogen catalogue, Mar. 1, 2005, pp. 1-2, XP002571024.
Communication dated Jan. 24, 2011, issued in corresponding European Application No. 08722165.1.
Ando Hiroshi
Kawamoto Shinobu
Nakamura Kazuyasu
Nakano Mariko
Ohta So
Dang Ian
Kyowa Hakko Kirin Co., Ltd.
Landsman Robert
Sughrue & Mion, PLLC
LandOfFree
Anti-claudin-4 antibody does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Anti-claudin-4 antibody, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Anti-claudin-4 antibody will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4258144