Anti-CD40CR MR1 antibody

Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Monoclonal antibody or fragment thereof

Reexamination Certificate

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C424S130100, C424S141100, C424S143100, C424S144100, C424S153100, C424S173100, C530S387100, C530S388200, C530S388220, C530S388700, C530S388730, C530S388750

Reexamination Certificate

active

07445781

ABSTRACT:
The present invention relates to a counter-receptor, termed CD40CR, for the CD40 B-cell antigen, and to soluble ligands for this receptor, including fusion molecules comprising at least a portion of CD40 protein. It is based, at least in part, on the discovery that a soluble CD40/immunoglobulin fusion protein was able to inhibit helper T-cell mediated B-cell activation by binding to a novel 39 kD protein receptor on helper T-cell membranes. The present invention provides for a substantially purified CD40CR receptor; for soluble ligands of CD40CR, including antibodies as well as fusion molecules comprising at least a portion of CD40 protein; and for methods of controlling B-cell activation which may be especially useful in the treatment of allergy or autoimmune disease.

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A. Desai-Mehta et al.: “Hypertension of CD40 Ligand by B and T Cells in Human Lupus and its Role in Pathogenic Autoantibody Production,” Journal of Clinical Investigation, vol. 9, No. 97, May 1, 1996, pp. 2063-2073, XP002080040.
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