Anti-CD40 monoclonal antibodies capable of blocking B-cell activ

Chemistry: molecular biology and microbiology – Spore forming or isolating process

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435 7021, 4351722, 53038822, 53038873, C12N 512, C07K 1528

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active

056771657

ABSTRACT:
Methods for preventing or treating an antibody-mediated diease in a patient are presented, the methods comprising administration of a monoclonal antibody capable of binding to a human CD40 antigen located on the surface of a human B cell, wherein the binding of the antibody to the CD40 antigen prevents the growth or differentiation of the B cell. Monoclonal antibodies useful in these methods, and epitopes immunoreactive with such monoclonal antibodies are also presented.

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