Chemistry: analytical and immunological testing – Involving an insoluble carrier for immobilizing immunochemicals – Carrier is organic
Patent
1995-07-19
1996-06-18
Housel, James C.
Chemistry: analytical and immunological testing
Involving an insoluble carrier for immobilizing immunochemicals
Carrier is organic
436528, 436547, 436548, 5303881, 5303911, 5303915, G01N 33548
Patent
active
055277136
ABSTRACT:
The invention describes the use of novel aminodextran compounds containing about 5-20% by weight amine groups to bind a plurality of monoclonal antibodies. The resulting antibody-aminodextran compounds may be used to induce the activation and proliferation of selected mammalian cells. Specific examples are given using an anti-CD3 monoclonal antibody conjugated two aminodextrans containing about 5% and 16%, respectively, by weight amine groups as an agent for inducing the activation and proliferation of T cells.
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Bolton Wade E.
Healy Cynthia G.
Kenyon Norma S.
Maples John A.
Siiman Olavi
Chi Christopher L.
Coulter Corporation
Housel James C.
Kaye Michelle A.
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