Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Reexamination Certificate
2011-03-08
2011-03-08
Dahle, Chun (Department: 1644)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
C530S387300, C530S387700, C530S388100, C530S388220, C530S388230, C530S388240, C530S388700, C530S388730, C530S388800, C530S391100, C530S391300, C530S391500, C530S391700
Reexamination Certificate
active
07902338
ABSTRACT:
The present invention provides humanized, chimeric and human anti-CD19 antibodies, anti-CD19 antibody fusion proteins, and fragments thereof that bind to a human B cell marker. Such antibodies, fusion proteins and fragments thereof are useful for the treatment and diagnosis of various B-cell disorders, including B-cell malignancies and autoimmune diseases. In more particular embodiments, the humanized anti-CD19 antibodies may comprise one or more framework region amino acid substitutions designed to improve protein stability, antibody binding and/or expression levels. In a particularly preferred embodiment, the substitutions comprise a the substitution of serine for phenylalanine at Kabat residue 91 in the human framework region in the hA19 VH sequence.
REFERENCES:
patent: 5530101 (1996-06-01), Queen et al.
patent: 5798554 (1998-08-01), Grimaldi et al.
patent: 6183744 (2001-02-01), Goldenberg et al.
patent: 6187287 (2001-02-01), Leung et al.
patent: 6306393 (2001-10-01), Goldenberg et al.
patent: 6653104 (2003-11-01), Goldenberg et al.
patent: 7109304 (2006-09-01), Hansen et al.
patent: 7462352 (2008-12-01), Hansen et al.
patent: 2003/0133930 (2003-07-01), Goldenberg et al.
patent: 2006/0257398 (2006-11-01), Hansen et al.
patent: 2008/0187966 (2008-08-01), Simmons
patent: 96/36360 (1996-11-01), None
patent: 00/74718 (2000-12-01), None
International Search Report for PCT/US09/61666, filed Oct. 22, 2009, date of mailing Mar. 16, 2010
Bataille et al. “The phenotype of normal, reactive and malignant plasma cells. Identification of “many and multiple myelomas” and of new targets for myeloma therapy” Haematologica Sep. 2006;91(9):1234-1240.
Cochlovius et al. “Treatment of Human B Cell Lymphoma Xenografts with a CD3 × CD19 Diabody and T Cells” the Journal of Immunology, 2000, 165: 888-895.
Ek et al. “Treatment of Human B-Cell Precursor Leukemia in SCID Mice by Using a Combination of the anti-CD19 Immunotoxin B43-PAP with the Standard Chemotherapeutic Drugs Vincristine, Methylprednisolone, and L-Asparaginase” Leukemia and Lymphoma, vol. 31, pp. 143-149.
Ghetie et al. “Homodimers but not monomers of Rituxan (chimeric anti-CD20) induce apoptosis in human B-lymphoma cells and synergize with a chemotherapeutic agent and an immunotoxin” Blood. 2001;97:1392-1398).
Ghetie et al. “Evalution of Ricin A Chain-containing Immunotoxins Directed against CD19 and CD22 Antigens on Normal and Malignant Human B-Cells as Potential Reagents for in Vivo therapy” Cancer Research 48, 2610-2617, 1988.
Ghetie et al. “Homodimerization of tumor-reactive monoclonal antibodies markedly increases their ability to induce growth arrest or apoptosis of tumor cells” Proc. Natl. Acad. Sci. USA vol. 94, pp. 7509-7514, Jul. 1997.
Ghetie et al. “The Antitumor Activity of an Anti-CD22 Immunotoxin in SCID Mice with Disseminated Daudi Lymphoma is Enhanced by Either an anti-CD19 Antibody or an Anti-CD19 Immunotoxin” Blood, vol. 80, No. 9 Nov. 1, 1992: pp. 2315-2320.
Hekman et al. “Initial experience with treatment of human B cell lymphoma with anti-CD19 monoclonal antibody” Cancer Immunol Immunother (1991) 32: 364-372.
Ma et al. “Radioimmunotherapy for model B cell malignancies using 90Y-labeled anti-CD19 and anti-CD20 monoclonal antibodies” Leukemia (2002) 16, 60-66.
Matsushita et al. “Inhibitory Role of CD19 in the Progression of Experimental Autoimmune Encephalomyelitis by Regulating Cytokine Response” American Journal of Pathology vol. 168(3):812-821 (2006).
Mitchell et al. “Targeting Primary Human Ph+ B-Cell Precursor Leukemia-Engrafted SCID Mice Using Radiolabeled Anti-CD19 Monoclonal Antibodies” J Nucl Med 2003; 44:1105-1112.
Patti et al. “High-dose cyclophosphamide, etoposide and BCNU (CVB) with autologous stem cell rescue in malignant lymphomas” Eur. J. Haematol 1993: 51: 18-24.
Pietersz et al. “In vitro and in vivo antitumour activity of a chimeric anti-CD19 antibody” Cancer Immunol Immunother (1995) 41: 53-60.
Roguska et al. “A comparison of two murine monoclonal antibodies humanized by CDR-grafting and variable domain resurfacing” Protein Engineering vol. 9, No. 10, pp. 895-904, 1996.
Roguska et al. “Humanization of murine monoclonal antibodies through variable domain resurfacing” Proc. Natl. Acad. Sci. USA vol. 91, pp. 969-973, Feb. 1994.
Rowland et al. “Preclinical invesigation of the antitumour effects of anti-CD19-idarubicin immunoconjugates” Cancer Immunol Immunother (1993) 37: 195-202.
Shan et al. “Signaling events involved in anti-CD20-induced apoptosis of malignant human B cells” Cancer Immunol Immunother (2000) 48:673-683.
Stone et al. “A phase I Study of Bolus Versus Continuous Infusion of the anti-CD19 Immunotoxin, IgG-HD37-dgA, in Patients with B-Cell Lymphoma” Blood, vol. 88, No. 4 (Aug. 15, 1996, pp. 1188-1197.
Uckun et al. “Treatment of Therapy-Refractory B-Lineage Acute Lymphoblastic Leukemia with an Apoptosis-inducing CD19-directed Tyrosine Kinase Inhibitor” Clinical Cancer Research vol. 5, 3906-3913, Dec. 1999.
Uckun et al. “Detailed Studies on Expression and Function of CD19 Surface Determinant by Using B43 Monoclonal Antibody and the Clinical Potential of Anti-CD19 Immunotoxins” Blood, vol. 71(1):13-29 (1988).
Uckun et al. “Effective Immunochemotherapy of CALLA +Cu+ Human Pre-B Acute Lymphoblastic Leukemia in Mice with Severe Combined Immunodeficency Using B43 (anti-CD19) Pokeweed Antiviral Protein Immunotoxin Plus Cyclophosphamide” Blood, vol. 79(12):3116-3129 (1992).
Zola et al. “Preparation and characterization of a chimeric CD19 monoclonal antibody” Immunology and Cell Biology (1991) 69, 411-422.
Goldenberg David M.
Hansen Hans J.
Qu Zhengxing
Dahle Chun
Immunomedics Inc.
Nakashima Richard A.
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