Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Monoclonal antibody or fragment thereof
Reexamination Certificate
2007-06-19
2007-06-19
Ulm, John (Department: 1649)
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Monoclonal antibody or fragment thereof
C424S133100, C424S144100, C514S002600, C530S388220
Reexamination Certificate
active
10832985
ABSTRACT:
The present invention relates to an antibody or functional fragment thereof which binds to a mammalian (e.g., human) CC-chemokine receptor 1 (CCR1) or a portion of the receptor and blocks binding of a ligand to the receptor. The invention further relates to a method of inhibiting the interaction of a cell bearing mammalian CCR1 with a ligand thereof, and to use of the antibodies and fragments in research, therapeutic, prophylactic and diagnostic methods.
REFERENCES:
patent: 5440021 (1995-08-01), Chuntharapai et al.
patent: 5543503 (1996-08-01), Chuntharapai et al.
patent: 5545806 (1996-08-01), Lonberg et al.
patent: 5545807 (1996-08-01), Surani et al.
patent: 5652133 (1997-07-01), Murphy
patent: 5677184 (1997-10-01), Onda et al.
patent: 43 32 256 (1995-03-01), None
patent: WO 94/11504 (1994-05-01), None
patent: WO 95/08576 (1995-03-01), None
patent: WO 98/38167 (1998-09-01), None
patent: WO 98/44953 (1998-10-01), None
patent: WO 99/15666 (1999-04-01), None
Pease, James E., et al., “The N-terminal Extracellular Segments of the Chemokine Receptors CCR1 and CCR3 Are Determinants for MIP-1α and Eotaxin Binding, Respectively, but a Second Domain Is Essential for Efficient Receptor Activation”,The Journal of Biological Chemistry, 273(32):19972-19976 (1998).
Su, Shao-bo, et al., “Determination of Expression of a C-C Chemokine Receptor, CC CKR1 on Leukocytes”, 6th International Workshop and Conference on Human Leukocyte Differentiation Antigens, Kobe, Japan, Nov. 10-14, 1996,Tissue Antigens, 48(4-2):389 (1996) Abstract No. CR-1-07.
Su, Shao-bo, et al., “Selective Inhibition of BFU-E Proliferation by Macrophage Inflammatory Protein (MIP)-1α by Interacting Mainly with CCR1” (fromNippon Neneki Gakkai Sokai Gakujutsu Shukai Kiroku, 27:287 (1997) Abstract No. 2P76).
Su, Shao-bo, et al., “Inhibition of Immature Erythroid Progenitor Cell Proliferation by Macrophage Inflammatory Protein-1α by Interacting Mainly With a C-C Chemokine Receptor, CCR1”,Blood, 90(2):605-611 (1997).
Murakami, Seishi, et al., “Human Hepatitis Virus X Gene Encodes a Regulatory Domain That Represses Transactivation of X Protein”,The Journal of Biological Chemistry, 269(21):15118-15123 (1994).
Su, Shao-bo, et al., “Preparation of Specific Polyclonal Antibodies to a C-C Chemokine Receptor, CCR1, and Determination of CCR1 Expression on Various Types of Leukocytes”,Journal of Leukocyte Biology, 60:658-666 (1996).
Sallusto, Federica, et al., “Rapid and Coordinated Switch in Chemokine Receptor Expression During Dendritic Cell Maturation”,Eur. J. Immunol., 28:2760-2769 (1998).
Neote, Kuldeep, et al., “Molecular Cloning, Functional Expression, and Signaling Characteristics of a C-C Chemokine Receptor”,Cell, 72:415-425 (1993).
“Flow Cytometry Kits for Cell Surface Staining” [online] 1998 [retrieved on Oct. 28, 1998]. Retrieved from the Internet:<URL:http://cytokine.rndsystems.com/search/mfs/02/subdoc/flow.html.
“Antibodies to Cytokines and Cytokine Receptors (A-H)” [online] 1998 [retrieved on Oct. 28, 1998]. Retrieved from the Internet:<URL:http://cytokine.rndsystems.com/search/mfs/02/subdoc/anti.html.
Schall, Thomas J., et al., “Molecular Cloning and Expression of the Murine RANTES Cytokine: Structural and Functional Conservation Between Mouse and Man”,Eur. J. Immunol., 22:1477-1481 (1992).
Forssmann, Ulf, et al., “CKβ8, A Novel CC Chemokine That Predominantly Acts on Monocytes”,FEBS Letters, 408:211-216 (1997).
Gong, Xiaoqi, et al., “Monocyte Chemotactic Protein-2 (MCP-2) Uses CCR1 and CCR2B as Its Functional Receptors”,The Journal of Biological Chemistry, 272(18):11682-11685 (1997).
Youn, Byung-S., “Molecular Cloning of Leukotactin-1: A Novel Human β-Chemokine, a Chemoattractant for Neutrophils, Monocytes, and Lymphocytes, and a Potent Agonist at CC Chemokine Receptors 1 and 3”,J. Immunol., 159:5201-5205 (1997).
Youn, Byung-S., et al., “Characterization of CKβ8 and CKβ8-1: Two Alternatively Spliced Forms of Human β-Chemokine, Chemoattractants for Neutrophils, Monocytes, and Lymphocytes, and Potent Agonists at CC Chemokine Receptor 1”,Blood, 91(9):3118-3126 (1998).
Nomura, Hideki, et al., “Molecular Cloning of cDNAs Encoding a LD78 Receptor and Putative Leukocyte Chemotactic Peptide Receptors”,International Immunology, 5(10):1239-1249 (1993).
Gao, Ji-Liang, et al., “Structure and Functional Expression of the Human Macrophage Inflammatory Proteins 1α/RANTES Receptor”,The Journal of Experimental Medicine, 177:1421-1427 (1993).
Bonecchi, Rafaella, et al., “Up-Regulation of CCR1 and CCR3 and Induction of Chemotaxis to CC Chemokines by INF-γ in Human Neutrophils”,The Journal of Immunology, 162(1):474-479 (1999).
Osbourn, J., et al., “Directed selection of MIP-1α neutralizing CCR5 antibodies from a phage display human antibody library”,Nature Biotechnology, 16: 778-781 (1998).
Jakobovits, A., et al., “Analysis of homozygous mutant chimeric mice: Deletion of the immunoglobulin heavy-chain joining region blocks B-cell development and antibody production”,Genetics, 90: 2551-2555 (1993).
Jakobovits, A., et al., “Germ-line transmission and expression of a human-derived yeast artificial chromosome”,Nature, 362: 255-258 (1993).
Sato, K., et al., “CC Chemokine Receptors, CCR-1 and CCR-3, are Potentially Involved in Antigen-Presenting Cell Function of Human Peripheral Blood Monocyte-Derived Dendritic Cells”,Blood93(1):34-42 (1999).
Durig, J. et al., “Expression of Macrophage Inflammatory Protein-1α Receptors in Human CD34+Hematopoietic Cells and Their Modulation by Tumor Necrosis Factor-α and Interferon-γ”,Blood92(9):3073-3081 (1998).
Johnston, B. et al., “Chronic Inflammation Upregulates Chemokine Receptors and Induces Neutrophil Migration to Monocyte Chemoattractant Protein-1”,Journal of Clinical Investigation103(9):1269-1276 (1999).
Förster, R., et al., “A general method for screening mAbs specific for G-protein coupled receptors as exemplified by using epitope tagged BLRI-transfected 293 cells and solid-phase cell ELISA,”Biochemical and Biophysical Research Communications 196(3):1496-1502 (1993).
Chuntharapai, et al., “Generation of Monoclonal Antibodies to Chemokine Receptors,”Methods in Enzymology288:15027 (1997).
Emrich, T., et al., “New monoclonal antibody against leucocyte specific G protein coupled receptor—useful e.g. as antiinflammatory agent and for diagnosis of immune status, tumours, etc.,” Abstract for reference DE 4332256C1 (AP).
Kassam Nasim
Newman Walter
Qin Shixin
Hamilton Brook Smith & Reynolds P.C.
Millennium Pharmaceuticals Inc.
Ulm John
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