Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Binds antigen or epitope whose amino acid sequence is...
Reexamination Certificate
2008-05-13
2008-05-13
Belyavskyi, Michail (Department: 1644)
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Binds antigen or epitope whose amino acid sequence is...
C424S141100, C530S387900, C530S388150
Reexamination Certificate
active
11186283
ABSTRACT:
The invention provides isolated nucleic acids molecules, designated CARK nucleic acid molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing CARK nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a CARK gene has been introduced or disrupted. The invention still further provides isolated CARK proteins, fusion proteins, antigenic peptides and anti-CARK antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
REFERENCES:
patent: 194006 (1992-04-01), None
patent: 00/73469 (2000-12-01), None
Colman et al., Research in Immunology (145(1):33-36, 1994.
Abaza et al., Journal of Protein Chemistry (11(5):433-444, 1992.
Lederman et al., Molecular Immunology (28:1171-1181, 1991.
Li et al in PNAS 77:3211-3214, 1980.
Wang et al. JBC 276:49213-49220.
Metzler et al. Nature Structural Biol. 1997; 4:527-531.
Van Regenmortel, A Companion to Methods of Enzymology 9:465-472, 1996.
“Hypothetical Protein” Nov. 12, 1999 (sequence) TrEMBL [online], Geneva, Switzerland, Swiss Institute of Bioinformatics [retrieved on Jan. 7, 2005]. Retrieved from the Internet: URL:http://expasy.ch.sprot/>. TrEMBL Accession No. Q9Y2V6.
Jeffrey, P. D. et al., “Chain A, Cyclin A—Cyclin-Dependent Kinase 2 Complex.” Jul. 14, 1996 (sequence) GenBank [online] Bethesda, MD, USA: National Center for Biotechnology Information [retrieved on Jan. 7, 2005]. Retrieved from the Internet: URL:http://www.ncbi.nlm.nih.gov/>. GenBank Accession No. AF261233.
Russo, A. A. et al., “Chain A, Phosphorylated Cyclin-Dependent Kinase-2 Bound to Cyclin A” Jul. 3, 1996 (sequence) GenBank [online] Bethesda, MD, USA: National Center for Biotechnology Information [retrieved on Jan. 7, 2005]. Retrieved from the Internet: URL:http://www.ncbi.nlm.nih.gov/>. GenBank Accession No. 1JST—A.
Sicheri, F. et al., “Chain A, Src Family Kinase Hck-Amp-PnP Complex” Feb. 20, 1997 (sequence) GenBank [online] Bethesda, MD, USA: National Center for Biotechnology Information [retrieved on Jan. 7, 2005] Retrieved from the Internet: URL: http://www.ncbi.nlm.nih.gov/>. GenBank Accession No. 1AD5—A.
Mohammadi, M. et al., “Chain A, Crystal Structure of the Tryosine Kinase Domain of Fibroblast Growth Factor Receptor 1” Feb. 8, 1997 (sequence) GenBank [online] Bethesda, MD, USA: National Center for Biotechnology Information [retrieved on Jan. 7, 2005]. Retrieved from the Internet: URL: http://www.ncbi.nlm.nih.gov/>. GenBank Accession No. 1FGK—A.
Lisziewicz, J. et al., “Protein Kinase (EC 2.7.1.37), cAMP-Dependent, catalytic chain 1—Yeast (Saccharomyces cerevisiae)” Jul. 21, 2000 (sequence) GenBank [online] Bethesda, MD, USA: National Center for Biotechnology Information [retrieved on Jan. 7, 2005]. Retrieved from the Internet: URL: http://www.ncbi.nlm.nih.gov/>. GenBank Accession No. OKBYC1.
Xu, W. et al., “Crystal Structure of Human Tyrosine-Protein Kinase C-Src” Jan. 24, 1997 (sequence) GenBank [online] Bethesda, MD, USA: National Center for Biotechnology Information [retrieved on Jan. 7, 2005]. Retrieved from the Internet: URL: http://www.ncbi.nlm.nih.gov/>. GenBank Accession No. 1FMK.
Ebina, Y. et al., “Insulin Receptor (Tyrosine Kinase Domain) Mutant with Cys 981 Replaced By Ser and Tye 984 Replaced by the Phe (C981s, Y984f)” Dec. 4, 1998 (sequence) GenBank [online] Bethesda, MD, USA: National Center for Biotechnology Information [retrieved on Jan. 7, 2005]. Retrieved from the Internet: URL: http://www.ncbi.nlm.nih.gov/>. GenBank Accession No. 1IRK.
Tan, J. L. et al., “Protein-Tyrosine Kinase (EC 2.7.1.112) 1—Slime Mole (Dictyostelium discoideum) (fragment)” Feb. 4, 2000 (sequence) GenBank [online] Bethesda, MD, USA: National Center for Biotechnology Information [retrieved on Jan. 7, 2005]. Retrieved from the Internet: URL:http://www.ncbi.nlm.nih.gov/>. GenBank Accession No. A35670.
NCI-CGAP, “ah70b01.s1 Soares—testis—NHTHomo sapienscDNA clone 1320937 3′, mRNA sequence” Dec. 29, 1998 (sequence) GenBank [online] Bethesda, MD, USA: National Center for Biotechnology Information [retrieved on Jan. 7, 2005]. Retrieved from the Internet: URL:http://www.ncbi.nlm.nih.gov./>. GenBank Accession No. AA758546.
Hwang, D. M. et al., “M186 Fetal Heart, Lambda ZAP ExpressHomo sapienscDNA 5′, mRNA sequence” Apr. 23, 1997 (sequence) GenBank [online] Bethesda, MD, USA: National Center for Biotechnology Information [retrieved on Jan. 7, 2005]. Retrieved from the Internet: URL:http://www.ncbi.nlm.nih.gov/>. GenBank Accession No. AA389675.
NCI-cGAP, “op74a11.s1 Soares—NFL—T—GBC—S1Homo sapienscDNA clone IMAGE: 1582556 3′, mRNA Sequence” Sep. 24, 1998 (sequence) GenBank [online] Bethesda, MD, USA: National Center for Biotechnology Information [retrieved on Jan. 7, 2005], Retrieved from the Internet: URL: http://www.ncbi.nlm.nih.gov/>. GenBank Accession No. AA938871.
Shinn, P. et al., “F2401.13 [Arabidopsis thaliana]” Jan. 16, 1998 (sequence) GenBank [online] Bethesda, MD, USA: National Center for Biotechnology Information [retrieved on Jan. 7, 2005]. Retrieved from the Internet; URL: http://www.ncbi.nlm.nih.gov/>. GenBank Accession No. AAB96858.
Connell, M, “Caenorhabditis eleganscosmid C24A1, complete sequence” Dec. 3, 2004 (sequence) GenBank [online] Bethesda, MD, USA: National Center for Biotechnology Information [retrieved on Jan. 7, 2005]. Retrieved from the Internet: URL: http://www.ncbi.nlm.nih.gov/>. GenBank Accession No. AF024491.
Miao, N. et al., “Rattus norvegicuspancreatic serine threonine kinase mRNA, complete cds.” Jun. 13, 1998 (sequence) GenBank [online] Bethesda, MD, USA: National Center for Biotechnology Information [retrieved on Jan. 7, 2005]. Retrieved from the Internet: URL:http://www.ncbi.nlm.nih.gov/>. GenBank Accession No. AF068261.
NCI-cGAP, “ow16c03.x1 Soares—parathyroid—tumor—NbHPAHomo sapienscDNA clone IMAGE: 1646980 3′ similar to WP: C24A1.3 CE08335, mRNA Sequence” Jun. 30, 1998 (sequence) GenBank [online] Bethesda, MD, USA: National Center for Biotechnology information [retrieved on Jan. 7, 2005]. Retrieved from the Internet: URL: http://www.ncbi.nlm.nih.gov/>. GenBank Accession No. AI040439.
NCI-cGAP, “qw21h08.x1 NCI—CGAP—Ut4Homo sapienscDNA clone IMAGE: 1991775 3′, mRNA Sequence” Dec. 21, 1998 (sequence) GenBank [online] Bethesda, MD, USA: National Center for Biotechnology Information [retrieved on Jan. 7, 2005]. Retrieved from the Internet: URL:http//www.ncbi.nlm.nih.gov/>. GenBank Accession No. AI289394.
NCI-cGAP, “qp98h10.x1 Soares—fetal—lung—NbHL19WHomo sapienscDNA clone IMAGE:1931107 3′ similar to WP: C24A1.3 CE08335, mRNA Sequence” Dec. 28, 1998 (sequence) GenBank [online ] Bethesda, MD, USA: National Center for Biotechnology Information [retrieved on Jan. 7, 2005]. Retrieved from the Internet: URL: http://www.ncbi.nlm.nih.gov/>. GenBank Accession No. AI333762.
NCI-cGAP, “tc09q12.x1 Soares—NhHMPu—S1Homo sapienscDNA clone IMAGE: 2063398 3′ similar to WP: C24A1.3 CE08335, mRNA Sequence” Mar. 18, 1999 (sequence) GenBank [online] Bethesda, MD, USA: National Center for Biotechnology Information [retrieved on Jan. 7, 2005]. Retrieved from the Internet: URL: http://www.ncbi.nlm.nih.gov/>. GenBank Accession No. AI375137.
NCI-cGAP, “te61c04.x1 Soares—NFL—T—GBC—S1Homo sapienscDNA clone IMAGE: 2091174 3′, mRNA Sequence” Mar. 28, 1999 (sequence) GenBank [online] Bethesda, MD, USA: National Center for Biotechnology Information [retrieved on Jan. 7, 2005]. Retrieved from the Internet: URL: http://w
Belyavskyi Michail
Millennium Pharmaceuticals Inc.
LandOfFree
Anti-Cark antibodies and uses therefor does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Anti-Cark antibodies and uses therefor, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Anti-Cark antibodies and uses therefor will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3957941