Anti-caries oral compositions

Details Anti-caries oral compositions Anti-caries oral compositions

1998-02-19

1999-11-23

Weddington, Kevin E.

Drug, bio-affecting and body treating compositions

Dentifrices

424687, A61K 716, A61K 3310

Patent

active

059895250

ABSTRACT:
The present invention relates to oral compositions containing anti-caries agents distributed in an oral vehicle. In particular, the present invention provides oral compositions containing calcium, arginine and a cariostatic anion distributed in an oral vehicle. A method for preparing oral compositions containing anti-caries agents is also provided by the present invention. A method of reducing dental caries is described which comprises delivering a therapeutically effective amount of an oral composition containing calcium, arginine and a cariostatic anion into the oral cavity.

REFERENCES:
patent: 4225579 (1980-09-01), Kleinberg
patent: 4367218 (1983-01-01), Jacobson
M.F. Cole and W.H. Bowen, "Effect of Sodium Phytate on the Chemical and Microbial Composition of Dental Plaque in the Monkey" -- J.Dent. Res., May-Jun. 1975, vol. 54, pp. 449-457.
Chemistry and Applications of Phytic Acid: An Overview --Edited by Ernst Graf, Pilatus Press, 1986 -- pp. 1-20.
H.W. Kaufman and I. Kleinberg, "Effect of pH on Calcium Binding By Phytic Acid and its Inositol Phosphoric Acid Derivatives and on the Solubility of their Calcium Salts" -- Archs Oral Bio., -- 1971, vol. 16 -- pp.445-460.
H.W. Kaufman and I. Kleinberg, "X-ray Diffraction Study of the Effect of Phytate on the In Vitro Formation of Calcium Phosphates" -- JADR Abstracts, 1973 -- p. 169.
H.W. Kaufman and I. Kleinberg, "Hydrolysis of Phytate and its Inositol Phosphate Intermediates by an Acid and an Alkaline Phosphatase" -- Archs Oral Bio., 1975, vol. 20 -- p. 157.
H.W. Kaufman and I. Kleinberg, "The Effect of pH on the Adsorption Properties of the Phytate Molecule", Archs Oral Biol., vol. 15, 1970 -- pp. 917-934.
I. Kleinberg, J.A. Kanapka, R. Chatterjee, D. Craw, N.D'Angelo and H.J. Sandham, "Metabolism of Nitrogen by the Oral Mixed Bacteria" -- In: Saliva and Dental Caries -- pp. 357-377 (1971).
D.S. Magrill, "The Reduction of the Solubility of Hydroxyapatite in Acid by Adsorption of Phytate from Solution", Archs Oral Biol., vol. 18, 1973 -- pp. 591-600.
T.H. Grenby, "Tests of Sodium Phytate as a Protective Agent Against Dental Caries in the Rate", Abstracts of Papers presented at the 18th ORCA Congress, 1972 -- pp. 82-83.
Eugene R. Morris, "Phytate and Dietary Mineral Bioavailability",Phytic Acid: Chemistry and Applications-- pp. 57-76. (1962).
Hakon Nordbo andGunnar Rolla, "Desprption of Salivary Proteins from Hydroxyapatite by Phytic Acid and Glycerophosphate andthe Plaque-Inhibiting Effect of the Two Compounds in Vivo", J. Dent. Res, May-Jun. 1972, vol. 3 -- pp. 800-802.
A. Wise, "Influence of Calcium on Trace Metal-Phytate Interactions", In: Phytic Acid: Chemistry and Applications, 1986, Edited by E. Graf, Pilatus Press, 1986 -- pp. 161-160.

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