Anti-cancer vaccine

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Cancer cell or component thereof

Reexamination Certificate

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C424S184100

Reexamination Certificate

active

07402317

ABSTRACT:
There is disclosed a method of preparing a vaccine suitable for administration to humans for the prevention or treatment of cancer. The vaccine is prepared by culturing human cancer cells in a serum-free medium and recovering from the culture medium the cell surface antigens shed from the human cancer cells during culturing. After purification, the collected or recovered shed antigens are employed to produce a vaccine consisting essentially of said antigens for the treatment or prevention of human cancer.

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patent: 5635188 (1997-06-01), Bystryn
patent: 5993829 (1999-11-01), Bystryn
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Bystryn et al (J. Biol. Resp. Mod. 1986; 5:211-224).
Gupta (Vaccines 1995;13(14):1263-1276).
Bystryn, J.-C. et al., “Immunogenicity of a Polyvalent Melanoma Antigent Vaccine in Patients with Early Melanoma ,” Proceedings of American Association for Cancer Research, vol. 26; Mar. 1985, p. 312, Abstract No., 1233.
Bystryn, J.-C. et al., “Effects of a Polyvalent Tumor Antigent Vaccine in Human Malignant Melanoma ,” Clinical Research, vol. 33; No. 2; Apr. 1985, p. 628A.

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