Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Cancer cell or component thereof
Patent
1994-12-30
1997-06-03
Feisee, Lila
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Cancer cell or component thereof
530350, 530395, 514 2, 514 8, 514 12, A01K 3900, C07K 1447
Patent
active
056351887
ABSTRACT:
A human anti-cancer vaccine is prepared by culturing human cancer cells, such as human melanoma cells, in a serum-free medium. The cancer cells are selected on the basis of expressing different patterns of cell surface tumor antigens and are adapted and grown in a serum-free medium. During culturing, cell surface antigens of the cancer cells are shed into the culture medium. The culture medium, after removal of the cancer cells, containing the shed cancer cell antigens is concentrated. When used as an anti-cancer vaccine, the resulting concentrated composition is administered to the patient, such as intradermally. In the instance where patients are cancer patients, the vaccine is administered to the patient intradermally over a period of weeks with or without an adjuvant.
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Feisee Lila
Reeves Julie E.
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