Anti-cancer quinazoline derivatives

Details Anti-cancer quinazoline derivatives Anti-cancer quinazoline derivatives

1990-12-12

1993-08-17

Ivy, C. Warren

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

544284, 544285, 544287, 544289, A61K 31505, C07D23984

Patent

active

052369277

ABSTRACT:
A compound of formula I: ##STR1## wherein R is hydrogen; oran alkyl, alkenyl or alkynyl group of up to 6 carbon atoms; nis O; 1 or 2; Z represents --CH.dbd.CH-- or --S--; each X independently represents halogeno, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, nitro or trifluoromethyl; and Y represents a group of formula: ##STR2## or a pharmaceutically acceptable salt or ester thereof.

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patent: 4447608 (1984-05-01), Jones et al.
patent: 4564616 (1986-01-01), Jones et al.
patent: 4992550 (1989-04-01), Hughes
Jones, et al., "Chemical Abstracts", vol. 106, 1987, col. 106:102679c. (Abstract of Eur. Pat. Appl. EP 204,529, Published Dec. 10, 1986).
Journal of the Chemical Society, 1953, Brown, "Some Pteridines related to Folic Acid . . . ".

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