Anti-cancer cyclopenta [ g ]quinazonline compounds

Details Anti-cancer cyclopenta [ g ]quinazonline compounds Anti-cancer cyclopenta [ g ]quinazonline compounds

2010-03-03

2011-11-22

Kosar, Andrew D (Department: 1622)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C544S249000

Reexamination Certificate

active

08063056

ABSTRACT:
Cyclopenta[g]quinazolines of the formula (I):—wherein:A is a group OR or NR0R1wherein R0and R1are each independently hydrogen C1-4alkyl, C3-4alkenyl, C3-4alkynyl, C2-4hydroxyalkyl, C2-4halogenoalkyl or C1-4cyanoalkyl, or R0and R1together with the intermediate N form a five- or six-membered heterocyclic ring;p is an integer in the range 1 to 4;R2is hydrogen, C1-4alkyl, C3-4alkenyl, C3-4alkynyl, C2-4hydroxyalkyl, C2-4halogenoalkyl or C1-4cyanoalkyl;Ar1is phenylene, thiophenediyl, thiazolediyl, pyridinediyl or pyrimidinediyl which may optionally bear one or two substituents selected from halogeno, hydroxy, amino, nitro, cyano, trifluoromethyl, C1-4alkyl and C1-4alkoxy; andR3is a group of one of the following formulae:in-line-formulae description="In-line Formulae" end="lead"?-A1-Ar2-A2-Y1-A5-CON(R)CH(Y4)Y5-A8-X—Ar4in-line-formulae description="In-line Formulae" end="tail"?and pharmaceutically acceptable salts or esters thereof are of therapeutic value particularly in the treatment of cancer.

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