Anti-cancer cyclopenta [G]quinazoline compounds

Details Anti-cancer cyclopenta [G]quinazoline compounds Anti-cancer cyclopenta [G]quinazoline compounds

2007-11-20

2007-11-20

Wilson, James O. (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C544S249000

Reexamination Certificate

active

10487871

ABSTRACT:
Cyclopenta[g]quinazolines of the formula (I):—wherein: A is a group OR or NR0R1wherein R0and R1are each independently hydrogen C1-4alkyl, C3-4alkenyl, C3-4alkynyl, C2-4hydroxyalkyl, C2-4halogenoalkyl or C1-4cyanoalkyl, or R0and R1together with the intermediate N form a five- or six-membered heterocyclic ring, p is an integer in the range 1 to 4, R2is hydrogen, C1-4alkyl, C3-4alkenyl, C3-4alkynyl, C2-4hydroxyalkyl, C2-4halogenoalkyl or C1-4cyanoalkyl; Ar1is phenylene, thiophenediyl, thiazolediyl, pyridinediyl or pyrimidinediyl which may optionally bear one or two substituents selected from halogeno, hydroxy, amino, nitro, cyano, trifluoromethyl, C1-4alkyl and C1-4alkoxy, and R3is a group of one of the following formulae: -A1-Ar2-A2-Y1-A5-CON(R)CH(Y4)Y5-A8-X—Ar4and pharmaceutically acceptable salts or esters thereof are of therapeutic value particularly in the treatment of cancer

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