Anti-cancer cyclopenta [G]quinazoline compounds

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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C544S249000

Reexamination Certificate

active

10487871

ABSTRACT:
Cyclopenta[g]quinazolines of the formula (I):—wherein: A is a group OR or NR0R1wherein R0and R1are each independently hydrogen C1-4alkyl, C3-4alkenyl, C3-4alkynyl, C2-4hydroxyalkyl, C2-4halogenoalkyl or C1-4cyanoalkyl, or R0and R1together with the intermediate N form a five- or six-membered heterocyclic ring, p is an integer in the range 1 to 4, R2is hydrogen, C1-4alkyl, C3-4alkenyl, C3-4alkynyl, C2-4hydroxyalkyl, C2-4halogenoalkyl or C1-4cyanoalkyl; Ar1is phenylene, thiophenediyl, thiazolediyl, pyridinediyl or pyrimidinediyl which may optionally bear one or two substituents selected from halogeno, hydroxy, amino, nitro, cyano, trifluoromethyl, C1-4alkyl and C1-4alkoxy, and R3is a group of one of the following formulae: -A1-Ar2-A2-Y1-A5-CON(R)CH(Y4)Y5-A8-X—Ar4and pharmaceutically acceptable salts or esters thereof are of therapeutic value particularly in the treatment of cancer

REFERENCES:
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Bavetsias, V. et al; “Design and Synthesis of Cyclopenta'g!quinazoline-based antifolates as inhibitors of thymidylate synthase and potential antitumor agents”;Journal of Medicinal Chemistry, American Chemical Society, Wash., US, vol. 43, No. 10, 2000, pp. 1910-1926-26; XP002187697.
Melin, C. et al; “Novel cyclopenta'g!quinazoline dipeptide antifolates: Thymidylate synthase inhibitors with activity independent of the reduced folate carrier and folylpolyglutamate synthetase”,Chemistry and Biology of Peteridines and Folates; 1997, Proceedings of the Int'l Symposium on Pteridines and Folates, 11th, Berchtesgaden, Germany; Eds. Pfleiderer, Wolfgang; Rokos, Hartmut; Publ.: Blackwell Wissenschafts-Verlag; Jun. 15-20, 1997, pp. 139-144, XP009000407.
Bavetsias, V. , et al; “Synthetis and antitumour activity of cyclopenta'g!quinazoline-based antifolates, a novel class of thymidylate synthase (TS) inhibitors”;Chemistry and Biology of Pteridines and Folates 1997, Proceedings of the Int'l Symposium on Pteridines and Folates, 11th, Berchtesgaden, Germany, Eds.: Pfleiderer, Wolfgang, Rokos, Hartmut; Publ.: Blackwell Wissenschafts-Verlag, Jun. 15-20, 1997, pp. 205-208, XP009000408.
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