Anti-cancer compounds and methods related thereto

Details Anti-cancer compounds and methods related thereto Anti-cancer compounds and methods related thereto

2006-07-04

2006-07-04

Kerr, Kathleen (Department: 1656)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C435S106000, C435S117000, C435S007230, C424S009100, C530S300000, C530S314000, C530S333000, C530S402000, C562S433000

Reexamination Certificate

active

07071168

ABSTRACT:
The present invention provides compounds useful to inhibit tumor growth and to induce apoptosis. In general, the anti-cancer agents (ACA) are described by the formula:in-line-formulae description="In-line Formulae" end="lead"?[ACA]n-X[Formula I]in-line-formulae description="In-line Formulae" end="tail"?wherein X is a linker group having 2–5 functional groups or is absent, n=1, and ACA is selected from the group consisting of Formula II, Formula III, Formula IV, Formula V, and Formula VI, as described herein. Other compounds described herein are defined by the Formula VII, as described herein.

REFERENCES:
patent: 5635593 (1997-06-01), Cheronis et al.
patent: 5849863 (1998-12-01), Stewart
patent: WO 97/09347 (1997-03-01), None
L. Gera et al.; “New Bradykinin Antagonists Having High Potency at Both B1 and B2 Receptors”; Peptides: Chemistry, Structure and Biology, Mayflower Scientific Ltd., 1996, pp. 348-349.
D. Chan et al.; “Novel Bradykinin Antagonist Dimers for the Treatment of Human Lung Cancers”; Immunopharmacology, vol. 33, 1996, pp. 201-204.
Stewart et al.; Can. J. Physiol Pharmacol. 75:719-724, 1997.

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