Anti-cancer composition comprising rhodacyanine compound and cyc

Details Anti-cancer composition comprising rhodacyanine compound and cyc Anti-cancer composition comprising rhodacyanine compound and cyc

1995-06-07

1997-09-23

Raymond, Richard L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514 58, 514314, 514338, 514367, 514369, 514375, 514376, 514443, A61K 31425

Patent

active

056705301

ABSTRACT:
An anti-cancer composition comprising a rhodacyanine compound and cyclodextrin or derivative thereof, wherein said rhodacyanine compound is selected from the group consisting of compounds represented by the following Formula (I), the cation moiety of which has a log P value of 4.5-12: ##STR1## wherein X.sub.1 and X.sub.2, which may be the same or different, each represents O, S, Se, ##STR2## Y.sub.1 represents O, S, Se, or ##STR3## R.sub.1 and R.sub.3, which may be the same or different, each represents an alkyl group;
R.sub.2 represents an alkyl group, an aryl group or a heterocyclic group;
Z.sub.1 and Z.sub.2, which may be the same or different, each represents an atomic group necessary to form a 5- or 6-membered ring;
L.sub.1, L.sub.2 and L.sub.3, which may be the same or different, each represents a methine group or nitrogen atom and L.sub.1 and R.sub.3 may combine and form a 5- or 6-membered ring;
R.sub.4 and R.sub.5, which may be the same or different, each represents an alkyl group;
R.sub.6 and R.sub.7, which may be the same or different, each represents an alkyl group or an aryl group;
Q represents a pharmaceutically acceptable anion;
j and k, which may be the same or different, each represents 1 or 2;
m and n, which may be the same or different, each represents 0 or 1.

REFERENCES:
patent: 4727064 (1988-02-01), Pitha

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