Anti-cancer agents and processes for their preparation

Details Anti-cancer agents and processes for their preparation Anti-cancer agents and processes for their preparation

1985-04-23

1987-07-28

Hollrah, Glennon H.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

C07C 5008, C07C 5006

Patent

active

046830871

ABSTRACT:
Compounds of the formula ##STR1## wherein R.sub.1 and R.sub.2 are either two hydrogen atoms or together form a methylene group, and each X is a bromo, iodo or tosyloxy group and the dotted bonds indicate that the central linkage is attached to the two phenyl rings at positions which are either meta to both CH.sub.2 X groups or para to both such groups, possess anti-cancer activity.
The active compounds are prepared by multi-step syntheses beginning with dimethoxymethylbenzaldehydes or di(hydroxymethyl)methoxyphenols; many of the intermediates involved are themselves novel.

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