Anti-cancer agents and androgen inhibition activity compound

Details Anti-cancer agents and androgen inhibition activity compound Anti-cancer agents and androgen inhibition activity compound

2011-06-14

2011-06-14

Shiao, Rei-tsang (Department: 1628)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Nitrogen containing other than solely as a nitrogen in an...

Reexamination Certificate

active

07960435

ABSTRACT:
A qualitative 3D pharmacophore model (a common feature based model or Catalyst HipHop algorithm) developed from well-known natural product androgen receptor down-regulating agents (ARDAs). The 3D pharmacophore model is used as a template in virtual screening compounds for new ARDAs. ARDA compounds and compounds that strongly inhibit the growth of human prostate LNCaP cells. The compounds may be used in compositions and methods of inhibiting cell proliferation of a cancer and methods of preventing or treating cancer, including prostate cancer.

REFERENCES:
patent: 2004/0167128 (2004-08-01), Comess et al.
patent: 1155119 (1961-07-01), None
patent: 1329349 (1963-06-01), None
patent: 30-9326 (1955-12-01), None
Purushottamachar et al., “First pharmacophore-based identification of androgen receptor down-regulating agents: Discovery of potent anti-prostate cancer agents”, Bioorganic & Medicinal Chemistry, 2007, pp. 3413-3421, Vo. 15.
Natarajan et al., “Novel Arylsulfoanilide-Oxindole Hybrid as an Anticancer Agent That Inhibits Translation Initiation”, Journal of Medicinal Chemistry, Oct. 7, 2004, pp. 4979-4982, vol. 47, No. 21.
Purushottamachar et al., “Potent anti-prostate cancer agents derived from a novel androgen receptor down-regulating agent”, Bioorganic & Medicinal Chemistry, 2008, pp. 3519-3529, vol. 16.
Fanta et al., Abstract of “Derivatives of 2-(nitromethyl)quinoxaline”, Journal of Heterocyclic Chemistry, 1966, pp. 525-526, 3(4).
Fadda et al., Abstract of “Synthesis of certain sulfonamides and aminopyranoquinoline derivatives from 4-hydroxyquinoline with biological interest”, Pharmazie, 1991, pp. 743-744, 46(10).
Fadda et al., Abstract of “Synthesis of certain sulfonamides and aminopyranoquinoline derivatives from 4-hydroxyquinoline with biological interest”, Journal of the Indian Chemical Society, 1991, pp. 393-395, 68(7).
Jeney et al., Abstract of “The bacteriostatic action of nitrated benzenesulfonanilides”, Zentralblatt fuer Bakteriologie, Parasitenkunde, Infektionskrankheiten und Hygiene, Abtelung 1: Medizinisch-Hygienische Bakteriologie, Virusforschung und Parasitologie, Originale, 1966, pp. 122-125, 199(1).
Nadvornik et al., Abstract of “Ortho effect in dissociation of substituted N-phenylbenzenesulfonamides”, Collection of Czechoslovak Chemical Communications, 2001, pp. 1380-1392, 66(9).
Bunce et al., Abstract of “N-(Nitrophenyl)benzamide and benzenesulfonamide derivatives by nucleopilic aromatic substitution”, Organic Preparations and Procedures International, 2004, pp. 482-487, 36(5).
Lutskii et al., Abstract of “Dipole moments of ortho- and meta-substituted benzene- and toluenesulfonamides and—sulfonates”, Vestnik Khar-kovskofo Politekhnicheskogo Instituta, 1969, No. 41, pp. 3-5.
Sheppard et al., Abstract of “Discovery and Optimization of Anthranilic Acid Sulfonamides as Inhibitors of Methionine Aminopeptidase-2: A Structural Basis for the Reduction of Albumin Binding”, Journal of Medicinal Chemistry, 2006, pp. 3832-3849, 49(13).
International Search Report issued Aug. 11, 2008 in Corresponding International Application No. PCT/US07/87631.

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