Anti-cancer agent

Details Anti-cancer agent Anti-cancer agent

2005-02-15

2005-02-15

Nickol, Gary (Department: 1642)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C424S198100, C514S012200, C530S395000

Reexamination Certificate

active

06855685

ABSTRACT:
The invention relates to an anti-cancer agent containing α-chain protein (α-fragment) of HGF (hepatocyte growth factor) as an active ingredient. The active ingredient of α-fragment has a specific suppressing effect on invasion and metastasis of cancer cells such as gallbladder cancer, lung cancer and other, which are highly metastatic and result in a high mortality. Therefore, the agent of the invention is used in treatment and prevention of cancer as an anti-cancer agent, and is extremely useful clinically.

REFERENCES:
patent: 0550296 (1993-07-01), None
patent: 625010 (1994-02-01), None
patent: 9205184 (1992-04-01), None
patent: 9323541 (1993-11-01), None
patent: 9406909 (1994-03-01), None
patent: WO 96 40914 (1996-12-01), None
Bardelli A et al J. Biotechnol Sep. 1994;37(2):109-122.*
Coffer A et al Biochem J. Aug. 1991;278(Pt1):35-41.*
Nakamura T et al Nature Nov. 1989;342(6248):440-443.*
Nakamura T et al FEBS Lett Nov. 1987;224(2):311-316.*
Nakamura et al., FEBS Letters, vol. 224, No, 2, pp. 311-316, Nov. 1987, Elsevier Science.
Nakamura et al., Nature, vol. 342, No. 6248, pp. 440-443, Nov. 23, 2989.
Bardelli et al., Journal of Biotechnology, vol. 37, pp. 109-122, Elsevier Science.
Coffer et al., Biochem. J., vol. 278, pp. 35-41, 1991.
Date et al., FEBS Letters, vol. 420, pp. 1-6, 1997.
Chan, et al;Science, vol. 254, Nov. 1991, pp. 1382-1385.
Lokker and Godowski;Journal of Biological Chemistry, vol. 268, No. 23, Aug. 15, 1993, pp. 17145-17150.
Tashiro, et al;Proc. Natl. Acad. Sci. USA: vol. 87, Apr. 1990, pp. 3200-3204.
Nakamura, et al.,Letters to Nature; vol. 342; Nov. 23, 1989; pp. 440-443.
Lomri, et al.,FEBS Letters; vol. 222, No. 2, Oct. 1987; pp. 311-316.
Nakamura, et al;Proc. Natl. Acad. Sci USA; vol. 83, Sep. 1986; pp. 6489-6493.
Nakamura, et al;Biochemical and Biophysical Research Communications; vol. 122, No. 3, Aug. 16, 1984; pp. 1450-1459.
Shimura, et al:Jpn. J. Cancer Res.; vol. 86 Jul. 1995; pp. 662-669.
Naldini, et al;Oncogene, vol. 6, 1991, pp. 501-504.
Bottaro, et al;Science, vol. 251, Feb. 15, 1991; pp. 802-804.
Nakamura, T.;Progress in Growth Factor Research, vol. 3, 1991, pp. 67-85.
Matsumoto, et al;Journal of Biological Chemistry, vol. 269, No. 50, Dec. 16, 1994; pp. 31807-31813.
Bellusci, et al;Oncogene, vol. 9, 1994, pp. 1091-1099.
Rahimi, et al;DNA and Cell Biology, vol. 13, No. 12, 1994; pp. 1189-1197.
Seslar, et al;Cancer Research; vol. 53, Mar. 15, 1993; pp. 1233-1238.
Jiang, et al.;Clin. Exp. Metastasis, vol. 11, 1993, pp. 235-242.
Rygaard, et al;Intern. J. Oncology, vol. 2, 1993, pp. 991-996.
Nakamura and Matsumoto;Gann Monograph on Cancer Research, No. 42, pp. 92-112.

Affiliated with

Also associated with

Rating

Anti-cancer agent does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Anti-cancer agent, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Anti-cancer agent will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3484952