Anti-cancer activity potentiator

Details Anti-cancer activity potentiator Anti-cancer activity potentiator

1989-08-08

1991-04-02

Cashion, Jr., Merrell C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Nitrogen containing other than solely as a nitrogen in an...

514937, 514938, A61K 31135

Patent

active

050047566

ABSTRACT:
A pharmaceutical oil-in-water type microemulsion having an action of potentiating the activities of anti-cancer agents, said micro-emulsion comprises fine particles of a vegetable oil or a triglyceride of a medium-chain fatty acid having 8 to 12 carbon atoms containing 0.1 to 10% (w/v) of N-solanesyl-N,N'-bis(3,4-dimethoxybenzyl)ethylenediamine malate of formula (I) below, ##STR1## an aqueous medium, and, 0.05 to 25% (w/v) of a physiologically acceptable phospholipid for dispersing said fine particles in said aqueous medium.

REFERENCES:
Enhancement of Chemotherapeutic Effect on Lymph Node Metastasis by Anticancer Agents in Fat Emulsion, Takahashi et al., Chemical Abstracts, 88, 1978, #126307t.
Anticancer Agents Containing Epidermal Growth Factor, Pseudomones Exotoxin Conjugate and N-Solanesyl-N,N'-bis(3,4 dimethoxybenzyl) Ethylene Diamine, Akiyama et al.
Chem. Abstracts, 109, 1988, #79750v.
Overcoming Drug Resistance in Cancer Cells with Synthetic Isoprenoids, Yamaguchi et al., JNCI 76, p. 947, 1986.
Reversal of Multi Drug Resistance by Synthetic Isoprenoids in the KB Human Cancer Cell Line, Nakagawa et al., Cancer Res. 46, 4453, 1986.

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