Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2006-06-20
2006-06-20
Davis, Zinna Northington (Department: 1625)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C514S185000, C546S002000, C546S010000
Reexamination Certificate
active
07064117
ABSTRACT:
This invention relates to a class of heterocycles and their metal complexes, and is particularly concerned with the use of these compounds in the preparation of prodrugs or as prodrugs that may be activated under hypoxic conditions by enzymes or by therapeutic ionising radiation, in the treatment of cancer. The invention also relates to the use of these heterocycles and the corresponding metal complexes in the preparation of medicaments and to compositions including the heterocycles or their metal complexes and to methods for preparing these compounds.
REFERENCES:
patent: WO 01/83482 (2001-11-01), None
patent: WO 200183482 (2001-11-01), None
Boger et al. J. Org. Chem. 2000, 65:4088-4100.
Sof'ina et al. Experimental Evaluation of Antitumor Drugs in the USA and USSR and Clinical Correlations. NCI Monograph 55. NIH Publication No. 80-1933 (1980), pp. 76-78.
Strandtmann et al. J. Med. Chem. (1967), 10(6):1063-1065.
Boger, et al; “Selective Metal Cation Activation of a DNA Alkylating Agent: Synthesis and Evaluation of Methyl 1,2,9,9a-Tetrahydrocyclopropa[c]pyrido[3,2-e]indol-4-one-7-carboxylate (CPyI)”, pp. 4088-4100; Journal of Organic Chemistry, vol. 65, No. 13, (2000).
Boger, D.L., et al; “A New Method of in Situ Activation for a Novel Class of DNA Alkylating Agents: Tunable Metal Cation Complexation and Activation”;J. Am. Chem. Soc.; vol. 122, pp. 6325-6326 (2000) XP002272345.
Atwell Graham John
Denny William Alexander
Milbank Jared Bruce
Stevenson Ralph James
Ware David Charles
Auckland Uniservices Limited
Davis Zinna Northington
Nixon & Vanderhye
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