Anti-bacterial T-cell factor

Details Anti-bacterial T-cell factor Anti-bacterial T-cell factor

1989-01-12

1991-05-28

Moskowitz, Margaret

Chemistry: molecular biology and microbiology

Spore forming or isolating process

435 702, 4351722, 935105, C12N 518, C12P 2100

Patent

active

050195131

ABSTRACT:
A method of protecting a mammal against a pathogenic bacterium by administering a soluble suppressor T-cell factor derived from a mammal that has been immunized with the bacterium or an antigenic surface fragment of the bacterium. Also disclosed are a hybrid cell fusion of an immunized suppressor T cell, methods of making such cells, and method of producing soluble suppressor T-cell factors.

REFERENCES:
Zalenznik et al., Clinical Res. 31(2):379A (1983).
Whitaker, R. B. and Ruddle, N. H. "Antigen-Specific T Cell Hybrids I. Ovalbumin Binding T Cell Hybrid," Cellular Immunology, vol. 55, No. 1, pp. 56-65, 1980.
Ginsburg, C. H. et al., "Prevention of Granuloma Development in the Mouse by Using T Cell Hybridoma Products," Journal of Immunology, vol. 132, No. 1, pp. 203-208, 1984.
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Healey et al. (1983), J. Immunology 131:2843-2847.
Lifshitz et al. (1983), Proc. Nat'l. Acad. Sci. 80:5689-5693.
Murphy et al. (1983), J. Immunol. 130:2876-2881.
Zaleznik et al. (1985), J. Clin. Invest. 75:1023-1027.
Zaleznik et al. (1984), "Cellular Immune Mechanisms in Experimental Gram-Negative Sepsis" Abstract, Meeting of the American Society of Microbiology.
Finberg et al. (1985), "Suppressor T Cell Hybridoma Factor Prevents Abscesses".

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