Anti-bacterial oral composition containing bis-biguanido hexanes

Details Anti-bacterial oral composition containing bis-biguanido hexanes Anti-bacterial oral composition containing bis-biguanido hexanes

1987-06-30

1992-03-31

Moezie, F. T.

Drug, bio-affecting and body treating compositions

Dentifrices

Fluorine or fluorine compound containing

424 49, 424 54, 424 58, 514901, A61K 718

Patent

active

051006502

ABSTRACT:
The invention provides an anti-bacterial oral composition such as mouthrinse which includes a bis-biguanido hexane compound such as chlorhexidine and compounds thereof, certain non-ionic surfactants which are poly(oxyethylene)-poly(oxypropylene) block copolymers having an HLB of between 10 and 30 or an ethoxylated hydrogenated caster oil containing from about 10 to 200 moles of added ethylene oxide and sorbitol in high concentrations. The oral composition is found to increase the activity of the bis-biguanido compound from 25% to 150%.

REFERENCES:
patent: 3976765 (1976-08-01), Nachtigal
patent: 4157387 (1969-06-01), Benedict
patent: 4528180 (1985-07-01), Schaeffer

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