Anti-bacterial agents based upon oxoanion binding

Details Anti-bacterial agents based upon oxoanion binding Anti-bacterial agents based upon oxoanion binding

2006-07-11

2006-07-11

Weddington, Kevin E. (Department: 1614)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Boron containing doai

C514S110000, C514S111000, C514S363000, C514S364000, C514S365000, C514S372000, C514S438000, C514S441000

Reexamination Certificate

active

07074776

ABSTRACT:
Compounds of the structure I:are useful for treating bacterial growth, wherein E is selected from the group consisting of B, P, and S, T1and T2are each independently selected from the group consisting of O, NR, and CH2, where R═H or C1–C8alkyl, or C1–C8oxoalkyl, and L is selected from the group consisting of ethylene, propylene, and four to six-membered alicyclic and aromatic rings, provided that structure I does not include AI-2-borate. The compounds may be used to treat bacterial infections in human beings and to regulate biofilm formation. Pharmaceutical compositions comprising one or more such compounds are useful for treating bacterial infections in human beings.

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