Anti-atherosclerotic pharmaceutical compositions containing diph

Details Anti-atherosclerotic pharmaceutical compositions containing diph Anti-atherosclerotic pharmaceutical compositions containing diph

1981-10-09

1983-11-22

Schwartz, Richard A.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Virus or component thereof

260931, 260932, A61K 3166

Patent

active

044168772

ABSTRACT:
The present invention relates to a pharmaceutical composition for increasing the relative quantity of circulating high density lipoproteins favorable augmentating the alpha/beta lipoprotein cholesterol ratios and clearing cholesterol and lipids from certain tissues and inducing hypotensive activity comprising administering to a human an effective amount of a compound of the formula: ##STR1## where X is H, OH, or ##STR2## R and R' identical or different are H, CH.sub.3 or C.sub.2 H.sub.5 ; m is zero or 1; and A is selected from the group comprising (CH.sub.3).sub.3 C--, Y--C.sub.6 H.sub.4 --, Y--C.sub.6 H.sub.4 --O--C(CH.sub.3).sub.2 --, Y--C.sub.6 H.sub.4 --C(CH.sub.3).sub.2 --, Y--C.sub.6 H.sub.4 --C(O)--C.sub.6 H.sub.4 --, Y--C.sub.6 H.sub.4 --(CH.sub.2).sub.n -- and Y--C.sub.6 H.sub.4 --O--(CH.sub.2).sub.n --, where n is an integer from 1 to 6 and Y is H, CH.sub.3, OCH.sub.3, a halogen, and a pharmaceutically acceptable excipient.

REFERENCES:
patent: 2848475 (1958-08-01), Schmidt
patent: 3299123 (1967-01-01), Fitch et al.
patent: 3463835 (1969-08-01), Budnick
patent: 4067971 (1978-01-01), Francis et al.
patent: 4113861 (1978-09-01), Fleisch et al.
patent: 4137309 (1979-01-01), Van Duzee
Pudovik et al., Index Chemicus, vol. 28; Issue 216; 1968.
Nicholson et al., J. Org. Chem., vol. 36; No. 24; 1971, pp. 3843-3845.
Kosolapoff et al., Organic Phosphorus Compounds, vol. 7, Wiley Interscience, New York, 1976, pp. 267, 269 and 270.

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