Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...
Patent
1998-02-05
2000-03-28
Geist, Gary
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Nitrogen containing other than solely as a nitrogen in an...
564199, 564211, 564162, 564163, 564164, 564 49, 564 51, 564 52, 564 53, 564152, 564155, 514478, 514482, 514485, 514488, 514533, 514534, 514539, 514540, 514592, 514596, 514597, 514598, 514618, 514619, 514620, 514622, 560 9, 560 11, 560 12, 560 13, 560 24, 560 27, 560 29, 560 30, 560 32, 560 33, A01N 3718, A01N 4710, C07C27102, C07C27530, C07C27540
Patent
active
060432845
ABSTRACT:
The present invention is concerned with diaryl compounds of formula (I) and their use in medical therapy, particularly in the prophylaxis or treatment of a clinical condition for which an ACAT inhibitor is indicated, such as hyperlipidaema or atherosclerosis. The invention also relates to pharmaceutical compositions and processes for the preparation of compounds according to the invention. ##STR1##
REFERENCES:
patent: 5824705 (1998-10-01), Mueller et al.
Jilek et al., Collect. Czech. Chem. Commun., 54(12), 3294-3339, 1989.
Watanabe et al., J. Org. Chem., 49(5), 742-747, 1984.
Adzima et al., J. Am. Chem. Soc., 100(3), 953-962, 1978.
Boruffini et al., Farmaco Ed. Sci., 26(10), 8910907, 1971.
Arrowsmith Richard James
Dann John Gordon
Franzmann Karl Witold
Hodgson Simon Teanby
Wates Peter John
Davis Brian J.
Geist Gary
Glaxo Wellcome Inc.
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