Anti-atherosclerotic aryl compounds

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – N-c doai

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514534, 514535, 514576, 514588, 514617, 514619, 560 34, 560 39, 560 43, 560 61, 562444, 562439, 562457, 562471, 564 48, 564161, 564163, 564169, A61K 3127, C07C22900, C07C27502, C07C23301

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active

056589441

ABSTRACT:
The present invention is concerned with compounds of formula (I) ##STR1## wherein Ar is a mono- or bicyclic aromatic group optionally containing one or two heteroatoms independently selected from nitrogen, oxygen and sulphur, said group being optionally substituted by one or more atoms or groups independently selected from halogen, nitro, amino, --NRR.sup.1 where R and R.sup.1 are independently selected from hydrogen, C.sub.1-8 alkyl and C.sub.1-8 alkanoyl, cyano, carboxyalkoxy, alkoxycarbonylalkoxy, C.sub.1-8 alkyl (including cycloalkyl and cycloalkylalkyl), C.sub.1-8 alkoxy (including cycloalkoxy and cycloalkylalkoxy), C.sub.1-8 thioalkyl, said alkyl, alkoxy and/or thioalkyl group(s) being optionally substituted by one or more halogen atoms, aryl, aryloxy, aralkyl and aralkyloxy, said aryl, aryloxy, aralkyl and/or aralkyloxy group(s) being optionally substituted by one or more atoms or groups independently selected from halogen, alkyl, alkoxy, alkanoyl, hydroxyalkyl, perfluoroalkyl, perfluoroalkoxy, carboxyalkoxy, alkoxycarbonylalkoxy, and C.sub.3-8 polyether groups containing from one to three oxygen atoms;

REFERENCES:
patent: 4387106 (1983-06-01), DeVries et al.
patent: 4397868 (1983-08-01), DeVries
patent: 4623662 (1986-11-01), Devries
Lalezari, et al., J. Med. Chem. 32(10), 2352-7 1989.
European Search Report.
J. Med. Chem., vol. 32, pp. 2352-2357, 1989.
Proc. Natl. Acad. Sci., vol. 85, pp. 6117-6121, 1988.

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