Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Radical -xh acid – or anhydride – acid halide or salt thereof...
Patent
1985-01-03
1986-04-22
Schenkman, Leonard
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Radical -xh acid, or anhydride, acid halide or salt thereof...
514826, A61K 3120
Patent
active
045843201
ABSTRACT:
A method for the treatment of asthma, nasal congestion and anaphylactic shock involves nasal or oral administration of 8,11,14,17-eicosatetraenoic acid. Pharmaceutical compositions for this purpose are prepared containing 8,11,14,17-eicosatetraenoic acid and pharmaceutically acceptable vehicles, as well as, preferably, a suitable anti-oxidant.
REFERENCES:
patent: 4377526 (1983-03-01), Fujita et al.
Chemical Abstracts 85: 137703f, (1976).
Burka, J. F. et al. "Effects of Modulators of Arachidonic Acid Metabolism of the Synthesis and Release of Slow-Reacting Substance of Anaphylaxis" Br. J. Pharmac. 65, pp. 35-41, (1979).
Hitchcock, M. et al., "Arachionic Acid Metabolism and Modulation of in vitro Anaphylaxis by 5, 8, 11, 14-eicosatetraynoic Acid and 9a,12a-Octadecadiynoic Acid", Br. J. Pharmac., 72, 689-695, (1981).
Yecies, L. D. et al., "Slow Reacting Substance (SRS) From Ionophore A23187-Stimulated Peritoneal Mast Cells of the Normal Rat", The Journal of Immunology, vol. 122, No. 5, pp. 2090-2095, (1979).
Crawford, M. A., "Background to Essential Fatty Acids and Their Prostanoid Derivatives", British Medical Bulletin, vol. 39, No. 3, pp. 210-213, (1983).
Higgs, G. A. et al., "Inhibition of Cyclo-Oxygenase and Lipoxygenase", British Medical Bulletin vol. 39, No. 3, pp. 265-270, (1983).
Taylor, G. W. et al., "Lipoxygenase Pathways", British Medical Bulletin, vol. 39, No. 3, pp. 219-222 (1983).
Jakschik, B. A. et al., "Fatty Acid Structural Requirements for Leukotriene Biosynthesis", Prostaglandins, vol. 20, No. 2, pp. 401-410, (1980).
Cohen, N. et al., "Analogs of Atachionic Acid Methylated at C-7 and C-10 as Inhibitors of Leukotriene Biosynthesis", Prostaglandins, vol. 27, No. 4, pp. 553-562, (1984).
Blackwell, G. J. et al., "1-Phenyl-3-Pyrazolidone: an Inhibitor of Cyclo-Oxygenase and Lipoxygenase Pathways in Lung and Platelets" Prostaglandins, vol. 16, No. 3, pp. 417-425, (1978).
Paterson, N. A. M., et al., "Release of Slow-Reacting Substance of Anaphylaxis from Dispersed Pig Lung Cells: Effect of Cyclo-Oxygenase and Lipoxygenase Inhibitors", J. Allergy Clin. Immunol. vol. 67, No. 6, pp. 425-434, (1981).
Nijkamp, F. P. et al., "Leukotrienes, Allergy and Inflammation", Pharmaceutisch Weekblad Scientific Edition, vol. 4, pp. 165-171, (1982).
Sirois, P. et al., "Les Leucotrienes", La Semaine des Hopitaux Paris No. 14, pp. 979-985, (1984).
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