Anti-asialo-GM1 monoclonal antibodies and method of use

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

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435 7021, 4351722, 43524027, 436548, 5303875, 53038873, 5303888, 53038885, 5303896, 5303897, G01N 3353, G01N 33577, C12N 520, C07K 1628

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054439574

ABSTRACT:
A monoclonal antibody which reacts with glycolipid asialo GM1 but not with any of glycolipids GM1 and GM2 can be produced by hybridoma cells obtained by fusing antibody-producing cells of a mammal immunized with the glycolipid asialo GM1 with myeloma cells.

REFERENCES:
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Kannagi et al. (Kannagi), "Monoclonal antibodies directed to carbohydrate antigens," Handbook of Experimental Immunology, vol. 4, 4th Ed., pp. 117.1-117.20.
Kasai, M. et al. "Aglycolipid on the Surface of Mouse Natural Killer Cells," Eur. J. Immunol. 10: 175-180, 1980.
Kuo, M.-C. et al. "Rabbit-Mouse Hybridomas Secreting Intact Rabbit Immunoglobulius," Molecular Immunology 22(4): 351-359, 1985.
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Society For Neuroscience Abstracts, Bol. 10, No. 1, 1984, p. 82, New York, U.S.
Molecular Immunology, vol. 22, No. 11, Nov. 1985, pp. 1265-1271, Pergamon Press Ltd., GB.
Pereira et al, "Immunochemical Studies on the Specificity of the Peanut (Arachis hypogaea) Agglutinin", Carbohydrate Research, 51, (1976) pp. 107-118.
Higashi et al. "Sensitive Enzyme-Immunostaining and Densitometric Determination on Thin-Layer Chromatography of N-Glycolylneuraminic Acid-Containing Glycosphingolipids, Hanganutziu-Deicher Antigens", J. Biochem 95, 1517-1520 (1984).
Uchida et al, "Affinity Chromatographic Purification of Anti-Glycolipid Antibodies and Their Application to the Membrane Studies", J. Biochem. 87 1829-1841 (1980).
Young et al, "Production of Monoclonal Antibodies Specific for Two Distinct Steric Portions of the Glycolipid Ganglio-N-Triocylceramide (Asialo GM.sub.2)" J. Exp. Med., 150, 1008-1018 (1979).
Kohler et al, "Continuous Cultures of Fused Cells Secreting Antibody of Predefined Specificity", Nature, 256, 495-497 (1975).
Sanai et al, "Enzyme-Linked Immunosorbent Assay (Elisa) for Detection of Antibodies against Glycosphingolipids and Its Application to Patients with Systemic Lupus Erythematosus", Japan. J. Exp. Med., 51, 309-316, (1981).
Taki et al, "Determination of Glycolipid in Sera from Cancer Patients by Elisa Method and its Application to Cancer Diagnosis", Proceedings of the Japanese Cancer Association, 1984, p. 418.

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