Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1994-04-08
1995-08-22
Budens, Robert D.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
435 7021, 4351722, 43524027, 436548, 5303875, 53038873, 5303888, 53038885, 5303896, 5303897, G01N 3353, G01N 33577, C12N 520, C07K 1628
Patent
active
054439574
ABSTRACT:
A monoclonal antibody which reacts with glycolipid asialo GM1 but not with any of glycolipids GM1 and GM2 can be produced by hybridoma cells obtained by fusing antibody-producing cells of a mammal immunized with the glycolipid asialo GM1 with myeloma cells.
REFERENCES:
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Kannagi et al. (Kannagi), "Monoclonal antibodies directed to carbohydrate antigens," Handbook of Experimental Immunology, vol. 4, 4th Ed., pp. 117.1-117.20.
Kasai, M. et al. "Aglycolipid on the Surface of Mouse Natural Killer Cells," Eur. J. Immunol. 10: 175-180, 1980.
Kuo, M.-C. et al. "Rabbit-Mouse Hybridomas Secreting Intact Rabbit Immunoglobulius," Molecular Immunology 22(4): 351-359, 1985.
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Pereira et al, "Immunochemical Studies on the Specificity of the Peanut (Arachis hypogaea) Agglutinin", Carbohydrate Research, 51, (1976) pp. 107-118.
Higashi et al. "Sensitive Enzyme-Immunostaining and Densitometric Determination on Thin-Layer Chromatography of N-Glycolylneuraminic Acid-Containing Glycosphingolipids, Hanganutziu-Deicher Antigens", J. Biochem 95, 1517-1520 (1984).
Uchida et al, "Affinity Chromatographic Purification of Anti-Glycolipid Antibodies and Their Application to the Membrane Studies", J. Biochem. 87 1829-1841 (1980).
Young et al, "Production of Monoclonal Antibodies Specific for Two Distinct Steric Portions of the Glycolipid Ganglio-N-Triocylceramide (Asialo GM.sub.2)" J. Exp. Med., 150, 1008-1018 (1979).
Kohler et al, "Continuous Cultures of Fused Cells Secreting Antibody of Predefined Specificity", Nature, 256, 495-497 (1975).
Sanai et al, "Enzyme-Linked Immunosorbent Assay (Elisa) for Detection of Antibodies against Glycosphingolipids and Its Application to Patients with Systemic Lupus Erythematosus", Japan. J. Exp. Med., 51, 309-316, (1981).
Taki et al, "Determination of Glycolipid in Sera from Cancer Patients by Elisa Method and its Application to Cancer Diagnosis", Proceedings of the Japanese Cancer Association, 1984, p. 418.
Iwata Daiji
Shimada Shizio
Sudo Tadashi
Budens Robert D.
Mitsui Toatsu Chemicals Inc.
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