Anti-arrhythmic 5-endo-substituted oxy-N-(aminoloweralkyl)bicycl

Details Anti-arrhythmic 5-endo-substituted oxy-N-(aminoloweralkyl)bicycl Anti-arrhythmic 5-endo-substituted oxy-N-(aminoloweralkyl)bicycl

1975-03-05

1976-09-14

Gotts, Lewis

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2602472A, 260268TR, 26029361, 260295T, 260295ST, 2603433R, 424248, 424250, 424267, 424274, C07D20948

Patent

active

039806677

ABSTRACT:
Series of 5-endo-benzoyloxy-N-[amino(lower)-alkyl]bicyclo[2.2.2]octane-2,3-di-endo-c arboxylic acid imides, 5-endo-(3-indolecarbonyloxy)-N-[amino-(lower)alkyl]bicyclo[2.2.2]octane-2, 3-di-endo-carboxylic acid imides, 5-endo-n-substituted-carbamoyloxy-N-[amino(lower)alkyl]bicyclo[2.2.2]octan e-2,3-di-endo-carboxylic acid imides and 5-endo-(1-naphthoyloxy)-N-[amino(lower)alkyl]bicyclo[2.2.2]octane-2,3-di-e ndo-carboxylic acid imides have been found to possess unique prophylactic and therapeutic activity as anti-arrhythmia agents. An example of such a compound possessing activity is 5-endo-(3-indolecarbonyloxy)-N-(3-dimethylaminopropyl)bicyclo[2.2.2]octane -2,3-di-endo-carboxylic acid imide hydrochloride of the formula ##SPC1##

REFERENCES:
patent: 3850922 (1974-11-01), Matuo et al.

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