Anti-arrhythimic 5-endo-(3-indolecarbonyloxy)-N-[amino-(lower)al

Details Anti-arrhythimic 5-endo-(3-indolecarbonyloxy)-N-[amino-(lower)al Anti-arrhythimic 5-endo-(3-indolecarbonyloxy)-N-[amino-(lower)al

1975-07-10

1976-09-14

Gotts, Lewis

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2602472A, 260268TR, 26029361, 2603433R, 424248, 424250, 424267, 424274, C07D20976

Patent

active

039806685

ABSTRACT:
A series of 5-endo-(3-indolecarbonyloxy)-N-[amino-(lower)alkyl]bicyclo[2.2.1]heptane-2 ,3-di-endo-carboxylic acid imides having the formula ##SPC1##
Wherein R.sup.1 is H, Cl, Br, F or (lower)alkyl, R.sup.7 is H or methyl, R.sup.2 and R.sup.3 are alike or different and each is H, Cl, Br, F, (lower)alkyl, nitro, CF.sub.3, OH or (lower)alkoxy, n is an integer of 2 to 4 inclusive and R.sup.4 and R.sup.5 are alike or different and each is H, (lower)alkyl or when taken together with the nitrogen a radical of the formula ##SPC2##
In which R.sup.6 is (lower)alkyl; or a pharmaceutically acceptable acid addition salt thereof have been found to possess unique prophylactic and therapeutic activity as anti-arrhythmia agents. An example of such a compound possessing excellent activity is 5-endo-(3-indolecarbonyloxy)-N-(3-dimethylaminopropyl)bicyclo-[2.2.1]hepta ne-2,3-di-endo-carboxylic acid imide hydrochloride.

REFERENCES:
patent: 3850921 (1974-11-01), Matno et al.
patent: 3850922 (1974-11-01), Matno et al.

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