Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Recombinant or stably-transformed bacterium encoding one or...
Reexamination Certificate
2006-05-30
2006-05-30
Chan, Christina (Department: 1644)
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Recombinant or stably-transformed bacterium encoding one or...
C530S333000
Reexamination Certificate
active
07052705
ABSTRACT:
Peptides that specifically interfere with the ability of VEGF165to interact with the NP-1 receptor or with a VEGFR-2/NP-1 co-receptor complex are disclosed. The inventive peptides are useful to control pathological angiogenesis, such as occurs in cancer and other diseases. The peptides are based on a combination of basic residues contained within Exon 6 of human placental growth factor (PIGF), coupled at the carboxyl terminus to either Exon 8 of VEGF165or Exon 7 of PIGF. The peptides behave as antagonists of VEGF165signaling through a mechanism that involves competition for VEGF165binding at either the VEGFR-2/NP-1 complex or NP-1, without affecting VEGF signaling through other pathways. This binding is sufficient to attenuate pathological angiogenesis such as occurs in tumor growth.
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Jones David R.
Rosenbaum Jan Susan
Whitaker George Brian
Chan Christina
Gregg, Esq. Valeta
Huynh Phuong
Regeneron Pharmaceuticals Inc.
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