Anti-androgenic pyrrolidines with tumor-inhibiting action

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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Details

C548S314700

Reexamination Certificate

active

07601748

ABSTRACT:
This invention relates to anti-androgenic N-[ω-[3-[4-cyano-3-(trifluoromethyl)-phenyl]-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl]alkyl]-substituted pyrrolidines of general formula I,with a strongly pronounced antiproliferative profile of action; process for the production of the compounds of general formula I, pharmaceutical preparations and the use for the production of pharmaceutical agents.

REFERENCES:
patent: 5411981 (1995-05-01), Gaillard-Kelly et al.
patent: 7138421 (2006-11-01), Cleve et al.
patent: WO 97/00071 (1997-01-01), None
patent: WO 00/37430 (2000-06-01), None
International Search Report dated Dec. 8, 2004 issued in PCT/EP2004/004225.
M. E. Van Dort, et al., American Chemical Society, (2000), pp. 3344-3347.
Golub et al., Science, vol. 286, Oct. 15, 1999, pp. 531-537.

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