Anti-amoebic vaccine

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Parasitic organism or component thereof or substance...

Reexamination Certificate

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C424S009100, C424S009200, C424S265100

Reexamination Certificate

active

07078044

ABSTRACT:
The invention relates to an anti-amoebic vaccine containing an oligopeptide which can be obtained from the microorganism Entamoeba histolytica or synthesized by known methods. The anti-amoebic vaccines are particularly effective against inflammation and liver abscesses resulting from amoebic invasion when administered to patients.

REFERENCES:
Rico, et al., Production of the Monocyte Locomotion Inhibitory Factory (MLIF) By Axenically GrownEntamoeba histoloytica: Synthesis or Degradation? Archives of Medical Research 28:S235-S236 (1997).
Sepulveda et al., “Immunology of Amoebiasis byEntamoeba histolytica,” pp. 170-191.
Kretschmer, et al., “Inhibition of human monocyte locomotion by products of axenically grownE. histolytica,” Parasite Immunology, 1985, pp. 527-543.
Rico et al., The Monocyte Locomotion Inhibitory Factor (MLIF) Produced by Anxenically GrownEntamoeba histolyticaFails to Affect the Locomotion and the Respiratory Burst of Human EosinophilsIn Vitro, Archives of Medical Research, vol. 28, Suppl., pp. S233-S234, 1997.
Kretschmer, et al., “The role of mannose in the receptor of the monocyte locomotion ;Inhibitory Factor Produced by Axenically GrownEntamoeba histolytica,” Parasitology Research(1989) 75:245-246.
Rico et al., “Cyclic Nucleotide Changes Induced in Human Leukocytes by a Product of Axenically GrownEntamoeba histolyticathat Inhibits Human Monocyte Locomotion,” Parasitology Research (1995) 81:158-162.
Scherer et al., “Inhibition of Contact Cutaneous Delayed Hypersensitivity Reactions to DNBc in Guinea Pigs by the Monocyte Locomotion Inhibitory Factor (MLIF) Produced by Axenically GrownEntamoeba histolytica,” Archives of Medical Research, vol. 28, Suppl., pp. S237-S238, 1997.

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