Anti-allergy treatment using 2-(substituted amino)-4,5-dihydro-4

Details Anti-allergy treatment using 2-(substituted amino)-4,5-dihydro-4 Anti-allergy treatment using 2-(substituted amino)-4,5-dihydro-4

1986-12-05

1989-07-04

Schenkman, Leonard

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514826, A61K 3134

Patent

active

048451223

ABSTRACT:
As an anti-allergic treatment for warm-blooded animals, therapeutic amounts of a compound having the formula I (including acid salts thereof) or II are administered: ##STR1## where; R is OR.sup.4 or NHR.sup.5 in which R.sup.4 is hydrogen or lower alkyl, R.sup.5 is selected from phenyl and phenyl monosubstituted with halogen, lower alkyl, lower alkoxy, R.sup.1 and R.sup.2 are independently hydrogen or lower alkyl, and

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Mester, I.; Ionescu, M. Phytochemistry 10, 2205, (1971), C.A. 129976a, vol. 75, 312, (1971).
Ramachandran, V. N.; Pai, B. R.; Somasundaram, N.; Swaninathan, C. S. Indian J. Chem. 11, 1088 (1973), C.A. 10872a 80, 440, (1974).
Gais, H. J.; Hafner, J. Heterocycles 4, 1921, (1976), C.A. 1212676 86, 542 (1977).
Yazima, T.; Munakat, K. Agic. Biol. Chem. 44, 235. (1980).
Capuano, L.; Fischer, W. Chem. Ber., 109, 212, (1976).
Mulholland, T. P. C.; Foster, R.; Haydock, D. B., J. Chem. Soc., Perkin Trans I 1972; 1225.
Ibrahim, N. S. et al., 2, Naturforsch., 40B, pp. 129-131, Mar. 1985.

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