Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1992-03-26
1993-06-08
Lee, Mary C.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
5483361, A61K 31415, C07D23364
Patent
active
052179869
ABSTRACT:
The compound of the formula ##STR1## is described. This compound is active in an H.sub.3 receptor assay and is an H.sub.3 antagonist. Accordingly, the compound of formula I is useful in the treatment of diseases and conditions such as asthma, rhinitis, airway congestion, inflammation, cardiac arrhythmias, hypertension, hyper and hypo motility and acid secretion of the gastrointestinal tract, hypo and hyper activity of the central nervous system (CNS), migraine, and glaucoma.
REFERENCES:
Gunasekera et al., Journal of Natural Products, vol. 52, No. 4, pp. 753-756 Jul.-Aug. (1989).
Cimino et al. Tetrahedron Letters, vol. 24, No. 29, pp. 3029-3032, 1983.
Xynas et al, Aust. J. Chem., (1989), 42, 1427-1433.
Coval Stephen
Gullo Vincent P.
Horan Ann C.
Patel Mahesh G.
Pomponi Shirley A.
Boxer Matthew
Dicker Eric S.
Harbor Branch Oceanographic Institution Inc.
Lee Mary C.
Maitner John
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