Anti-allergic 3-indolecarboxamides

Details Anti-allergic 3-indolecarboxamides Anti-allergic 3-indolecarboxamides

1984-08-10

1986-03-18

Schwartz, Richard A.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

260239B, 2602457, 514323, 514414, 546201, 546223, 548467, 548557, A61K 3155, A61K 31445, C07D40112

Patent

active

045769400

ABSTRACT:
3-Indolecarboxamide compounds of the formula: ##STR1## inclusive of pharmaceutically acceptable acid addition salt and/or hydrate forms thereof, wherein R.sup.1 is C.sub.1-8 alkyl, C.sub.3-8 cycloalkyl, C.sub.3-8 cycloalkyl-C.sub.1-8 alkyl, allyl, propargyl, or phenyl or phenyl-C.sub.1-4 alkyl which may be optionally substituted, on the benzene ring, by at least one substituent selected from the group consisting of halogen, trifluoromethyl, C.sub.1-4 alkyl and C.sub.1-4 alkoxy; R.sup.2 is H or C.sub.1-6 alkyl; R.sup.3 is H, halogen, C.sub.2-6 alkanoyloxy, benzoyloxy, C.sub.1-4 alkoxy, benzyloxy, hydroxy or C.sub.1-4 alkyl; R.sup.4 is H, halogen, C.sub.1-4 alkyl, C.sub.1-4 alkoxy or hydroxy; R.sup.5 is H or C.sub.1-4 alkoxy; A is ethylene or trimethylene, which may be optionally substituted by C.sub.1-4 alkyl; n is zero, 1 or 2; and m is zero or 1, are useful as drugs for the prevention and treatment of various allergic diseases.

REFERENCES:
patent: 2814625 (1957-11-01), Speeter et al.
patent: 3527761 (1970-09-01), Archibald et al.
patent: 4064255 (1977-12-01), Champseix et al.
Archibald, J. et al., J. Med. Chem., 1971, 14(11), 1054-1059.
March, Advanced Organic Chemistry, 1st Ed., McGraw-Hill, 1968, p. 336.

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