Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1994-12-02
1996-07-09
Goldberg, Jerome D.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514279, A61K 31435
Patent
active
055345239
ABSTRACT:
An anti-AIDS virus composition comprising a therapeutically effective amount of cepharanthine or a pharmaceutically acceptable salt thereof and a method for treating AIDS which comprises administering a therapeutically effective amount of cepharanthine or a pharmaceutically acceptable salt thereof are disclosed.
REFERENCES:
Japanese Pharmacology & Therapeutics, vol. 17, No. 11, Nov. 1989, pp. 239-243, JP; K. Shimura: "Effect of cepharanthin on complement C3 and peritoneal macrophages in mice" (Abstract)(only).
Immunobiology, vol. 170, No. 4, Nov. 1985, pp. 351-364; Y. Nihashi et al.: "Thymus-dependent increase in number of T cells in parathymic lymph nodes . . . " Abstract only, p. 352; pp. 361-363.
Japanese Journal of Cancer and Chemotherapy, vol. 15, No. 1, 1988, pp. 127-133, JP; M. Ono et al.: "Augmentation of murine organ-associated natural immune responses by cepharanthin" Abstract (only).
"The Merck Manual," 15th edition, 1987, pp. 288-294, Merck & Co., Inc., Rahway, N.J.
Planta Medica, vol. 56, Dec. 1990, pp. 654-655; International Symposium, "Biology and Chemistry of Active Natural Substances," Bonn, 17th-22nd, Jul. 1990; K. Fujitani et al.: Inhibitory effect . . . .
Journal of the Medical Society of Toho University, vol. 34, No. 3.4, Nov. 1987, pp. 280-285; Shirai et al.: "Interferon inducing activity of cepharanthin and the effect of cepharanthin . . . ".
Sei Marianna Ika Daigaku Zasshi, vol. 9, No. 3, 1981, pp. 253-265; T. Kuramori et al.: "Effect of cepharanthin on cellular immunity" Abstract only.
Nippon Igaku Hoshasen Gakkai Zasshi, vol. 37, No. 12, 1977, pp. 1153-1167; R. Makidono et al.: "Leukopenia and lymphopenia during the radiation therapy and their recovery by . . . " Abstract only.
Journal of Ethnopharmacology, vol. 20, pp. 107-120, 1987.
Merck Index 11, p. 306, 1981 Cepharanthine, 1989.
Science, vol. 249, pp. 1533-1543, Sep. 1990.
Biochemical Pharmacology, vol. 39, No. 7, pp. 1255-1259, 1990.
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Akasu Michinori
Ono Minoru
Tamura Yuka
Goldberg Jerome D.
Kaken Shoyaku Co., Ltd.
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