Anti-aging and wound healing compounds

Details Anti-aging and wound healing compounds Anti-aging and wound healing compounds

2006-08-22

2006-08-22

Tate, Christopher R. (Department: 1654)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

Reexamination Certificate

active

07094754

ABSTRACT:
The invention provides inhibitors of matrix metalloproteinases that are useful for encouraging the development of healthy skin and for treating wounds. The inhibitors are peptides having sequences related to cleavage regions of the proenzyme forms of matrix metalloproteinases. The peptide inhibitors of the invention can be formulated into therapeutic compositions, lotions, creams, skin covering and wound dressings that facilitate healing and healthy skin development, discourage scarring and wrinkling and ameliorate the effects of healing.

REFERENCES:
patent: 4424552 (1984-01-01), Marcoux
patent: 5270447 (1993-12-01), Liotta et al.
patent: 5280106 (1994-01-01), Liotta et al.
patent: 5372809 (1994-12-01), Liotta et al.
patent: 5585356 (1996-12-01), Liotta et al.
patent: 5698671 (1997-12-01), Stetler-Stevenson et al.
patent: 5770691 (1998-06-01), Fields et al.
patent: 5811252 (1998-09-01), Verheijen
patent: 5869277 (1999-02-01), Stetler-Stevenson et al.
patent: 6043087 (2000-03-01), Bini et al.
patent: 6127139 (2000-10-01), Te Koppele et al.
patent: 6184022 (2001-02-01), Seiki et al.
patent: 6191225 (2001-02-01), Barkac et al.
patent: 6204043 (2001-03-01), Shapiro
patent: H1973 (2001-07-01), Hu
patent: 6274703 (2001-08-01), Goldberg
patent: 6399371 (2002-06-01), Falduto et al.
patent: 6482802 (2002-11-01), Hu et al.
patent: 6812339 (2004-11-01), Venter et al.
patent: 6906036 (2005-06-01), Quirk et al.
patent: 2001/0016333 (2001-08-01), Seiki et al.
patent: 2001/0031478 (2001-10-01), Bronstein et al.
patent: 2003/0012794 (2003-01-01), Srivastava et al.
patent: 2003/0096757 (2003-05-01), Quirk et al.
patent: 2003/0166567 (2003-09-01), Quirk et al.
patent: 2003/0199440 (2003-10-01), Dack et al.
patent: 2004/0010001 (2004-01-01), Au et al.
patent: 2004/0259802 (2004-12-01), Yang et al.
patent: 0917165 (1999-05-01), None
patent: 06213888 (1994-05-01), None
patent: 06300757 (1994-10-01), None
patent: 07159402 (1995-06-01), None
patent: 08134098 (1996-05-01), None
patent: 08136548 (1996-05-01), None
patent: 08217800 (1996-08-01), None
patent: 09023889 (1997-01-01), None
patent: 09084589 (1997-03-01), None
patent: 09087299 (1997-03-01), None
patent: 09136841 (1997-05-01), None
patent: 09206099 (1997-08-01), None
patent: 10210982 (1998-08-01), None
patent: 10287700 (1998-10-01), None
patent: 10313896 (1998-12-01), None
patent: 2000270874 (2000-10-01), None
patent: 2001011093 (2001-01-01), None
patent: WO 90/10228 (1990-09-01), None
patent: WO 94/10208 (1994-05-01), None
patent: WO 96/18725 (1996-06-01), None
patent: WO 97/25437 (1997-07-01), None
patent: WO 98/04287 (1998-02-01), None
patent: WO 98/12309 (1998-03-01), None
patent: WO 98/31818 (1998-07-01), None
patent: WO-9834641 (1998-08-01), None
patent: WO 98/40475 (1998-09-01), None
patent: WO 98/42865 (1998-10-01), None
patent: WO 99/05261 (1999-02-01), None
patent: WO-9958126 (1999-11-01), None
patent: WO 99/65519 (1999-12-01), None
patent: WO 00/20860 (2000-04-01), None
patent: WO 00/63227 (2000-10-01), None
patent: WO-0074634 (2000-12-01), None
patent: WO 01/10437 (2001-02-01), None
patent: WO 01/38558 (2001-05-01), None
patent: WO 01/62206 (2001-08-01), None
patent: WO 01/62261 (2001-08-01), None
patent: WO-03018748 (2003-03-01), None
ågren, Magnus S., “Matirx Metalloproteinases (MMPs) are Required for Re-epitheliazation..”,Arch Dermatol Res, (1999), 583-590.
Attie, Kenneth M., “Genetic Studies in Idiopathic Short Stature”,Current Opinion in Pediatrics, (2000), 400-404.
Azzam, H.S., et al., “Association of MMP-2 Activation Potential with Metastatic . . . ”,J Natl Cancer Inst, (1993), 1758-1764.
Becker, Joseph W., et al., “Stromelysin—1: Three-dimensional Structure of the Inhibited . . . ”,Protein Science, (1995), 1966-1976.
Bhide, V.M., et al., “Use of a Fluorogenic Septapeptide Matrix Metalloproteinase Assay . . . ”,J PeriodontolMay, (2000), 690-700.
Bickett, D.M., et al., “A High Throughput Flurogenic Substrate for Interstitial Collagenase . . . ”,Anal Biochem, (1993), 58-64.
Bickett, D.M., et al., “A High Throughput Fluorogenic Substrate for Stromelysin (MMP-3)”,Ann N Y Acad Sci, (1994), 351-355.
Blaschke, Rüdiger J., et al., “Shox: Growth, Léri-Weill and Turner Syndromes”,TEM, vol. 11, No. 6, (2000), 227-230.
Bremer, C., et al., “In Vivo Molecular Target Assessment or Matrix Metaloproteinase . . ”,Nat Med, (2001), 743-748.
Brown, P.D., et al., “Cellular Activation of the 72 kDa type IV Procollagenase/TIMP-2 . . . ”,Kidney Int, (1993), 163-170.
Brown, Rebeccah L., et al., “PDGF and TGF-a Act Synergistically to Improve Wound Healing . . ”,Journal of Surgical Research, vol. 56, No. 6, (1994), 562-570.
Browner, Michelle F., et al., “Matrilysin-Inhibitor Complexes: Common Themes among Metalloproteases”,Biochemistry, vol. 34, (1995), 6602-6610.
Cabrele, Chiara, et al., “Y-receptor Affinity Modulation by the Design of Pancreatic . . ”,Peptides, vol. 22, (2001), 365-378.
Calabrese, Edward J., “Cell Migration / Chemotaxis: Biphasic Dose Responses”,Critical Reviews in Toxicology, vol. 31, Issues 4 & 5, (2001), 615-624.
Calvin, Melissa, “Cutaneous Wound Repair”,Wounds: A Compendium of Clinical Research and Practice, vol. 10, No. 1, (1998), 12-32.
Chen, L.C., et al., “Disruption of the Cysteine-75 and Zinc Ion Coordination is Not Sufficient . . ”,Biochemistry, (1993), 10289-10295.
Chin, Jason W., et al., “Concerted Evolution of Structureand Function in a Miniature Protein . . . ”,J Am Chem Soc, vol. 123, No. 12, (2001), 2929-2930.
Chin, Jason W., et al., “Methodology for Optimizing Functional Miniature Proteins Based on Avian . . . ”,Bioorganic&Medicinal Chemistry Letters, vol. 1, (2001), 1501-1505.
Clark, Richard A.F., “Wound Repair”,The Molecular and Cellular Bilogy of Wound Repair, 2nd Ed., (1996), 3-50.
Wound Repair, 2nd Ed., (1996), 3-50.
Colandrea, Teresa D., et al., “Epidermal Expression of Collagenase Delays Wound-Healing . . . ”,The Journal of Investigative Dermatology, vol. 111, No. 6, (1998), 1029-1033.
Duivenoorden, Wilhelmina C.M., et al., “Use of Tetracycline as an Inhibitor of Matrix Metalloproteinase . . . ”,Invasion Metastasis, (1997), 312-322.
Duncan, M.E., et al., “Human Matrix Metalloproteinase-9: Activation by Limited Trypsin”,Eur J Biochem, Nov. 15, 1998.
Farmer, W.H., et al., “A Continuous Fluorescent Assay for Measuring Protease Activity . . . ”,Anal Biochem, (1991), 347-352.
Fernandez-Catalan, Carlos, et al., “Crystal Structure of the Complex Formed by the Membrane Type . . . ”,The EMBO Journal, vol. 17, No. 17, (1998), 5238-5248.
Freije, J.M., et al., “Molecular Cloning and Expression of Collagenase-3, a Novel . . . ”,J Biol Chem, Jun. 17, (1994), 16766-16773.
Freire, E., et al., “Calorimetrically Determined Dynamics Of Complex Unfolding . . . ”, Annual Review ofBiophysics and Biphysical Chemistry, vol. 19, (1990), 19:159-88.
Garbett, E.A., et al., “Proteolysis in Human Breast and Colorectal Cancer”,Br J Cancer, (1999), 287-93.
Gomis-Ruth, Franz-Xaver, et al., “Mechanism of Inhibition of the Human Matrix Metalloproteinase . . . ”,Nature, vol. 389, Issue 6646, (1997), 77-81.
Grams, Frank, et al., “X-ray Structures of Human Neutrophil Collagenase Complexed . . . ”,European Journal of Biochemistry, vol. 228, (1995), 830-841.
Guex, Nicolas, et al., “Swiss-Model and the Swiss-PdbViewer: An Enviroment for Comparative . . . ”,Electrophoresis, vol. 18, No. 15, (1997), 2714-2723.
Higgins, Desmond G., et al., “Clustal V: Improved Software for Multiple Sequence Alignment”,Computer Applications in the Biosciences, vol. 8, No. 2, (1992), 189-191.
Hilpert, Kai, et al., “Characterizing and Optimizing Protease / Peptide Inhabitor Interactions . . . ”,J Bio

Affiliated with

Also associated with

Rating

Anti-aging and wound healing compounds does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Anti-aging and wound healing compounds, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Anti-aging and wound healing compounds will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3606284