Anti-AGE IgG and uses thereof for the diagnosis of severe diseas

Details Anti-AGE IgG and uses thereof for the diagnosis of severe diseas Anti-AGE IgG and uses thereof for the diagnosis of severe diseas

1998-02-17

2000-08-08

Chan, Christina Y.

Chemistry: analytical and immunological testing

For preexisting immune complex or auto-immune disease

Immune complex

436509, 435 71, 435 792, 5303872, 530868, G01N 33564

Patent

active

061000981

ABSTRACT:
The present invention relates to the diagnosis of severe diseases based on the determination of the presence of AGE-IgG autoantibodies in patients and to a method of treatment thereof. More precisely, the invention relates to a method for the diagnosis of severe diseases in patients, which comprises the steps of: a) incubating a solid support coated with an AGE antibody with a biological sample from said patient for a time sufficient for an immunoreaction to occur; and b) determining the presence of AGE-IgG autoantibodies present in said sample; whereby the presence of AGE-IgG autoantibodies in said patient's sample is indicative of a severe disease. Such severe diseases which may be diagnosed in accordance with the present invention include Rheumatoid arthritis, atherosclerosis, amyloidosis, diabetes, Henoch Schonlein Purpura, Crohn's disease and Coeliac disease.

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