Anti-acne use of derivatives of (5,4b)-isothiazolo pyridine-3-on

Details Anti-acne use of derivatives of (5,4b)-isothiazolo pyridine-3-on Anti-acne use of derivatives of (5,4b)-isothiazolo pyridine-3-on

1983-11-23

1985-10-22

Schenkman, Leonard

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514859, A61K 31435

Patent

active

045489424

ABSTRACT:
An anti-acne composition comprises in a carrier suitable for topical application to the skin an active compound having the formula ##STR1## wherein R.sub.1 is linear or branched alkyl having 1-12 carbon atoms, mono- or polyhydroxyalkyl having 2-5 carbon atoms, alkenyl having 3-6 carbon atoms, cycloalkyl having 3-6 carbon atoms, or a radical of the formula ##STR2## wherein n is 0 or 1, m is 1, 2 or 3, R.sub.2 is hydrogen or lower alkyl having 1-3 carbon atoms and R.sub.3 represents hydrogen, alkyl having 1-4 carbon atoms, nitro, --CF.sub.3 or halogen. The acid salts of these active compounds can also be used.

REFERENCES:
patent: 3965107 (1976-06-01), Rainey et al.
Journal of Heterocyclic Chemistry, Nov.-Dec. 1982, vol. 19, No. 6, pp. 1393-1396.
Die Pharmazie, Sep. 1974, pp. 561, 597-602.
Chemical Abstracts, 88:50843q, 1978, (Baggaley).

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