Anti-acne composition containing a Poria cocos wolf extract

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing compound containing a...

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4352541, 435911, 552540, 552546, C12P 3300

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active

057168008

DESCRIPTION:

BRIEF SUMMARY
The present invention essentially concerns the use of a Poria cocos Wolf fungus extract for the preparation of a cosmetic or pharmaceutical composition, in particular a dermatological composition, for the treatment of acne or oily skin, and a cosmetic treatment method.
The article in "Revue Bulletin de la Societe Chimique de France" (1980, No. 9-10, pp 473-477) describes the use of Poria cocos Wolf fungus extracts, more particularly triterpenes contained in these extracts, which have cytotoxic activity for the treatment of tumors.
Further, the database Excerpta Medica contains an English abstract of the Japanese review "Japan Journal of Pharmacology" (1992), volume 59 (1), pp 89-96, which describes an antinephritic activity in a Poria cocos Wolf fungus extract.
Still further, published Japanese application number JP-A-1/038010 POLA describes a cosmetic composition for encouraging hair restoration and hair growth containing, among a number of active ingredients, an organic extract, in particular an alcoholic extract, of Poria cocos Wolf fungi.
Within the context of the present invention, we have unexpectedly discovered that organic or hydro-organic extracts of Poria cocos Wolf fungi exhibit a novel anti-ache activity and an oily skin controlling activity.
The aim of the present invention is thus to solve the novel technical problem with a solution which provides novel cosmetic or pharmaceutical formulations, in particular dermatological compositions, with an anti-acne and/or oily skin control activity in a simple, reproducible, inexpensive manner which can be used on an industrial scale and cosmetically and/or pharmaceutically.
The present invention satisfactorily solves this novel technical problem for the first time.
In a first aspect, therefore, the present invention concerns the use of an organic or hydro-organic extract of Poria cocos Wolf fungi for the manufacture of a cosmetic and/or pharmaceutical composition, in particular a dermatological composition, for the treatment of acne and oily skin.
Within the context of the invention, the expression "hydro-organic extract" means an extract obtained from a mixture of water and an organic solvent which is miscible with water. In particular, within the context of the present invention, a hydro-alcoholic mixture is preferably used, such as a hydro-ethanolic or a hydro-methanolic mixture, again preferably containing at least 50% by weight of alcohol with respect to the total weight of the hydro-alcoholic mixture.
In a particular embodiment, an alcoholic extract is used, in particular an entirely ethanolic extract, or a hydro-alcoholic extract such as a hydro-ethanolic or hydro-methanolic extract of Poria cocos Wolf.
In another particular embodiment, the concentration of Poria cocos extract is in the range 0.001% to 5% by weight with respect to the total weight of the final composition.
In yet another particular embodiment, the extract is at least partially incorporated into hydrated lamellar lipid phases or into liposomes.
In a still further particular embodiment, the Poria cocos extract is combined with at least one other active ingredient, preferably selected from the group consisting of a seboregulatory substance, an antiseptic substance, an anticomedo substance and an anti-inflammatory substance.
In still another particular embodiment, the seboregulatory substance is an extract of licorice, glycyrrhiza glabra.
In a further particular embodiment, the antiseptic substance is an anti-corynebacterium substance such as hexamidine diisethionate, which is commercially available, an isodon japonicus extract, which is commercially available, clindamycin, or erythromycin.
In still another particular embodiment, the anticomedo substance is selected from the group consisting of acid vitamin A, vitamin A and its derivatives such as the acetate, palmirate, propionate and azelaic acid.
In still another particular embodiment, the anti-inflammatory substance is selected from the group consisting of ammonium glycyrrhyzinate, glycyrrhetinic acid, a-bisabolol, tocopherol pho

REFERENCES:
patent: 3010878 (1961-11-01), Pan et al.
patent: 3369032 (1968-02-01), Diassi et al.
"Review Bulletin de la Societe Chimique de France" (1980, No. 9-10, pp. 473-477).
"Japan Journal of Pharmacology" (1992), vol. 59 (1), pp. 89-96.
"Studies on Antinephritic Effects of Plant Component of Poria cocos Wolf on Original-Type Anti-GBM Nephritis in Rats".

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