Anthrax specific antibodies

Details Anthrax specific antibodies Anthrax specific antibodies

2001-04-30

2009-11-17

Graser, Jennifer E (Department: 1645)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

C435S004000, C435S007200, C435S007320, C435S007720, C435S975000, C530S387100, C530S388100, C530S388200, C530S388400, C424S164100

Reexamination Certificate

active

07618783

ABSTRACT:
The present invention is directed to diagnostic tools and therapies using antibodies toBacillus anthracis.Specifically, the present invention is directed to aB. anthracis-specific monoclonal antibody that binds to the EA1 antigen (corresponding to the eag gene) of the S-layer (surface layer) of spores. This monoclonal antibody may be used in a variety of applications, including to specifically detect and diagnoseB. anthracis.Preferably, antibodies are monoclonal and bind to a surface protein, such as EA1 protein, on the spores ofB. anthracis,and not to spores of eitherB. cereusorB. thuringiensis.Antibodies can be incorporated into detection kits using, for example, colloidal particle based lateral flow detection system. Such detection kits can distinguish anthrax spores from non-pathogenic varieties of spores. In addition, the invention is directed toB. anthracisEA1 antigen and pharmaceuticals such as vaccines that can be used as therapeutics and to develop improved antibodies and detection methods.

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