Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving hydrolase
Reexamination Certificate
2007-02-27
2007-02-27
Prouty, Rebecca E. (Department: 1652)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving hydrolase
C435S221000, C435S194000, C435S007230, C435S007400, C435S007210
Reexamination Certificate
active
11326985
ABSTRACT:
The present invention relates to in vitro and ex vivo methods of screening for modulators, homologues, and mimetics of lethal factor mitogen activated protein kinase kinase (MAPKK) protease activity, as well as methods of treating cancer by administering LF to transformed cells.
REFERENCES:
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Duesbery, Nicholas S., et al., “Proteolytic Inactivation of MAP-Kinase—Kinase by Anthrax Lethal Factor,”Science, May 1, 1998, pp. 734-737, vol. 280.
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Duesbery Nicholas
Leppla Stephen
Vande Woude George
Webb Craig
Price Heneveld Cooper DeWitt & Litton LLP
Prouty Rebecca E.
The United States of America as represented by the Department of
Walicka Malgorzata A.
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