Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving hydrolase
Reexamination Certificate
2006-06-06
2006-06-06
Prouty, Rebecca E. (Department: 1652)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving hydrolase
C435S004000, C435S194000
Reexamination Certificate
active
07056693
ABSTRACT:
The present invention relates to in vitro and ex vivo methods of screening for modulators, homologues, and mimetics of lethal factor mitogen activated protein kinase kinase (MAPKK) protease activity, as well as methods of treating cancer by administering LF to transformed cells.
REFERENCES:
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Kimpel, K.R., et al., “Anthrax toxin lethal factor contains a zinc metalloprotease consensus sequence which is required for letal toxin activity,”Molecular Microbiology, 1994, pp. 1093-1100, vol. 13, No. 6.
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Menard, Armelle, et al., “The cytotoxic activity of Bacillus anthracis lethal factor is inhibited by leukotriene A4hydrolase and metallopeptidase inhibitors,”Biochem. J., 1996, pp. 687-691, vol. 320.
Oka, H., et al., “Constitutive Activation of Mitogen-Activated Protein (MAP) Kinases in Human Renal Cell Carcinoma,”Cancer Res., 1995, pp. 4182-4187, vol. 18.
Weinstein, John N., et al., “An Information-Intensive Approach to the Molecular Pharmacology of Cancer,”Science, Jan. 17, 1997, pp. 343-349, vol. 275.
Duesbery Nicholas
Leppla Stephen
Vande Woude George
Webb Craig
Prouty Rebecca E.
The United States of America as represented by the Department of
Townsend and Townsend / and Crew LLP
Walicka Malgorzata A.
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