Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving viable micro-organism
Reexamination Certificate
2011-01-18
2011-01-18
Weber, Jon P (Department: 1657)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving viable micro-organism
C435S023000, C435S007950, C435S183000, C435S221000
Reexamination Certificate
active
07871790
ABSTRACT:
Based on the observation that exposure of cells or animals to anthrax lethal toxin results in activation of the intracellular enzyme caspase-1/IL-1 converting enzyme (ICE), which, in turn, leads to production and extracellular release of the cytokine substrates of ICE: interleukin 1 beta (IL-1β) and interleukin 18 (IL-18), disclosed herein are bioassays that can be used to determine the efficacy of a potential anthrax therapeutic agent and for screening test agents to identify anthrax therapeutic agents. Also disclosed herein are methods of diagnosing and treating anthrax infection.
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Cordoba-Rodriguez Ruth
Frucht David M.
Klarquist & Sparkman, LLP
Srivastava Kailash C
The United States of America as represented by the Department of
Weber Jon P
LandOfFree
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