Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Radical -xh acid – or anhydride – acid halide or salt thereof...
Patent
1995-08-23
1997-09-16
Prior, Kimberly J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Radical -xh acid, or anhydride, acid halide or salt thereof...
514715, 552261, 552262, A61K 3119, G07C 5018
Patent
active
056681720
ABSTRACT:
A pharmaceutical compound of the formula ##STR1## in which R is hydrogen, halo or F.sub.2 HCO--; or a salt, amide or ester thereof, useful in the treatment of skeletal diseases.
REFERENCES:
patent: 3752813 (1973-08-01), Shen et al.
patent: 3984429 (1976-10-01), Peel et al.
patent: 3984534 (1976-10-01), Peel et al.
patent: 4226784 (1980-10-01), Kalopissis et al.
patent: 4244968 (1981-01-01), Freidmann
patent: 4363743 (1982-12-01), Moeller et al.
patent: 4402854 (1983-09-01), Moeller et al.
patent: 4456545 (1984-06-01), Weber et al.
patent: 4762648 (1988-08-01), Stache et al.
patent: 4950687 (1990-08-01), Dall 'Asta et al.
patent: 4966918 (1990-10-01), Watanabe et al.
patent: 5030387 (1991-07-01), Matsuoka et al.
patent: 5393898 (1995-02-01), Carcasona et al.
patent: 5480873 (1996-01-01), Brunavs et al.
Rosini, et al., Patents Preview Abstract of WO92/19584-A1, Published Nov. 12, 1992.
May, et al., Patents Preview Abstract of EP 454,058-A2, Published Oct. 30, 1991.
Arai, et al., "Amide Ion Formation and N-Alkylation of Aminoanthraquinones in the Presence of Potassium Hydroxide in Dimethyl Sulfoxide", Bull. Chem. Soc. Japan, 58(5), 1458-1463 (1985).
Dreyfus, et al., "Synthese de substances macromoleculaires renfermant des motifs monomeres derives de colorants", Bull. Soc. Chem. France, 5-6, 1196-1200 (1975).
Katzhendler, et al., "Synthesis of aminoanthraquinone derivatives and their in vitro evaluation as potential anti-cancer drugs", Eur. J. Med. Chem., 24, 23-30 (1989).
Peters, et al., "Structure-property relationships in 1,2,4-tri-donor-substituted anthraquinones-2-amino-1,4-dihydroxyanthraquinones", J. Soc. Dyers Colour, 105, 315-321 (1989).
Castle, et al., "The Synthesis of some Monomethylanthracenamines", Chem. Abstr, 116: 105789f (1992).
Sal'nikova, et al., "Substituted Amedic of 2-anthraquinonesuccinamenic acid: Synthesis and Study of Their Pharmacological Activity", Chem. Abstr., 113:204406 (1990).
Alemayehu, et al., "Quinones of Senna didymobotrya", Chem. Abstr., 112:52218c (1990).
Horner, et al., "Corrosion Inhibitors 23(1)", Chem. Abstr., 90:91154a (1979).
Metwally, "Reaction of Hydroxymethylanthraquinones with Thionyl Chloride", J. Appl. Chem. Biotechnol., 25, 161-168 (1975).
Alexander, et al., "Methylation and Hydroxylation Studies on Aloe-emodin", J. Org. Chem., 45, 20-24 (1980).
Yamada, et al., "Electrophotographic Photoreceptor Using Disazo Compound Charge-generating Agent", Chem. Abstr., 115:194178a(1991) of JP03 69,962.
Hayashi, et al., "Colored Rubbers and Rubber Additives", Chem. Abstr., 113:25368r (1990).
Proter Derwent Abstract 84-020099/04 of J5 8210-009-A (1984).
Proter, Derwent Abstract 83-17972k/08 of FR 2508-798 (1983).
Proter, Derwent Abstract 79-66382B/37 of BE-875-945 (1979).
Antonello, et al., "Diethylaminopropionamido-hydroxy-anthraquinones as Potential Anticancer Agents: Synthesis and Characterization", Arch. Pharm. (Weinheim), 322, 541-544 (1989).
Chemical Abstracts, 31: Abstract No. 3040(7), (1937).
Mosby, et al., "Products of Nucleophilic Displacement Reactions in the Anthraquinone Series", Tetrahedron, 8, 107-115 (1960).
Slavik, et al., "Substitution of NH Hydrogen in Nitrogen Derivatives of Polycyclic Hydrocarbons and Quinones", Coll. Czech. Chem. Comm., 4 (40), 1193-1198 (1975).
Chemical Abstracts, 84, (6) Abstract No. 32527c, 78, (1976).
Budziarek, Richard, "The Reaction of Sodium Sulphite and Bisulphite with Nitro-and Hydroxylamino-Anthraquinones", Chem. Ind., 15, 583-584 (1978).
Chemical Abstracts, 92, (1), Abstract No. 6302W, 592-593 (1980).
Chemical Abstracts, 95, (17), Abstract No. 150250g, 628, (1981).
Summers, et al., "Hydroxamic Acid Inhibitors of 5-Lipooxygenase: Quantitative Structure-Activity Relationships", J. Med. Chem., 33 (3), 992-998 (1990).
Beilsteins Handbuch der Organischen Chemie, 4th Edition, 3rd Supplement, 10, Part 5, 4787-4790 (1972).
Gallagher Peter Thaddeus
Owton William Martin
Williams Andrew Caerwyn
Leeds James P.
Lilly Industries Limited
Prior Kimberly J.
Strode Janelle D.
LandOfFree
Anthraquinone pharmaceutical compounds and uses therefor does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Anthraquinone pharmaceutical compounds and uses therefor, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Anthraquinone pharmaceutical compounds and uses therefor will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-218781