Anthraquinone-derivatives oligonucleotides

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai

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536 245, C07H 1700, A61K 3170

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active

052141365

ABSTRACT:
Oligonucleotide sequences modified by conjugation to at least one unsubstituted or substituted anthraquinone at other than the 5' terminus have favorable properties in enhancing hybridization to target DNA or RNA without loss of specificity and show enhanced stability to nucleases.

REFERENCES:
Chem. Abst. 114: 78183d, 1991.
Chem. Abst. 114: 43432g, 1991.
Ogilvie et al., Pure and Appl. Chem. (1987) 59(3):325-330.
Froehler et al., Nucleic Acids Res. (1986) 14(13):5399-5407.
Asseline et al., Tetrahedron Letters (1989) 30(19): 2521-2524.
Bayard et al., Biochemistry (1986) 25:3730-3736.
Lemaitre et al., Nucleosides and Nucleotides (1987) 6 (1&2):311-315.
Zuckerman et al., Nucleic Acids Res. (1987) 15(13):5305-5321.
Lancelot et al., Biochemistry (1985) 24:2521-2529.
Asseline et al., Proc. Natl. Acad. Sci. (1984) 81:3297-3301.
Mori et al., FEBS Letters (1989) 249(2):213-218.
van der Krol et al., Biotechniques (1988) 6(10):958-976.
Stein et al., Cancer Res. (1988) 48:2659-2668.

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