Anthranilic acid esters

Details Anthranilic acid esters Anthranilic acid esters

1981-08-31

1982-10-12

Breitenstein, G. T.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

560 45, 560 46, 560 47, 424230, 424310, C07C10154, A61K 31245

Patent

active

043540333

ABSTRACT:
Anthranilic acid esters having the generic formula: ##STR1## have been discovered. In the above formula (I) R.sub.1, R.sub.2 and R.sub.3 represent any of hydrogen, chlorine, methoxy and methyl groups and X represents a straight or branched alkyl chain comprising 1 to 4 carbon atoms. These esters are anti-inflaments, blood platelet aggregation inhibitors and prostaglandin synthetase inhibitors.
The compounds of the above formula (I) may be prepared by reacting alkali metal salt of a compound of the formula (II): ##STR2## in which R.sub.1, R.sub.2, R.sub.3 and X are the same as before with the compound of formula (III): ##STR3## in which R.sub.3 has the same meaning as before and z represents a chlorine or a bromine radical.

REFERENCES:
patent: 3313848 (1967-04-01), Scherrer et al.
patent: 3852333 (1974-12-01), Fisher
patent: 4135050 (1979-01-01), Hess et al.

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