Anthranilic acid derivative or salt thereof

Details Anthranilic acid derivative or salt thereof Anthranilic acid derivative or salt thereof

2011-08-16

2011-08-16

Sullivan, Daniel (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

C562S433000, C514S561000, C514S563000

Reexamination Certificate

active

07999132

ABSTRACT:
An anthranilic acid derivative represented by the general formula (X) [wherein R1represents hydrogen or a carboxy-protecting group; R2represents optionally substituted phenyl, a heterocyclic group, etc.; R3represents optionally substituted phenyl, a monocyclic heterocyclic group, etc.; X1represents carbonyl, etc.; X2represents optionally substituted alkylene group, a bond, etc.; X3represents oxygen, a bond, etc.; and X4represents a group represented by the general formula —X5—X6— or —X6—X5— (wherein X5means oxygen, a bond, etc.; and X6means optionally substituted alkylene, a bond, etc.)] or a salt of the derivative. The derivative or salt has the inhibitory activity of MMP-13 production and is hence useful as a therapeutic agent for articular rheumatism, osteoarthritis, cancer, etc.

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