Anthranilic acid amides and pharmaceutical use thereof

Details Anthranilic acid amides and pharmaceutical use thereof Anthranilic acid amides and pharmaceutical use thereof

2006-06-27

2006-06-27

Davis, Zinna Northington (Department: 1625)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C546S336000, C514S619000, C564S169000

Reexamination Certificate

active

07067543

ABSTRACT:
The invention relates to anthranilic acid amide derivatives of formula (I), wherein Ar is represented by the subformula (Ia), wherein Rarepresents H or lower alkyl, and R1represents H or perfluoro lower alkyl, R2represents H, halogen, C2–C7alkyl, C2–C7alkenyl or lower aklynyl; or Ar is represented by the subformula (Ib) and R1represents perfluoro lower alkyl, and R2represents bromo, iodo, C2–C7alkyl, C2–C7alkenyl or lower alkynyl, or R1represents H, and R2represents fluoro, bromo, iodo, ethyl, C5–C7alkyl, C2–C7alkenyl or lower alkynyl; to N-oxides and tautomers thereof, and to salts of such anthranilic acid amides, its N-oxides and tautomers; to processes for their preparation; to their application in the treatment of the human or animal body, to the use thereof—alone or in combination with one or more other pharmaceutically active compounds—for the treatment especially of a neoplastic disease, such as a tumor disease, of retinopathy or age-related macular degeneration; to a method for the treatment of such diseases in animals; and to the use of such a compound—alone or in combination with one or more other pharmaceutically active compounds—for the manufacture of a pharmaceutical preparation for the treatment of a neoplastic disease, of retinopathy or age-related macular degeneration.

REFERENCES:
patent: 3226394 (1965-12-01), Schipper
patent: WO 00/27820 (2000-05-01), None

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